**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-EPCAM rabbit polyclonal antibody at 1:500 dilution
Lane A: HepG2 Whole Cell Lysate
Lane B: 293T Whole Cell LysateLysates/proteins at 20 μg per lane.
Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.Developed using the Odyssey technique.
Performed under reducing conditions.Predicted band size:35 kDa
Observed band size:38 kDa
(We are unsure as to the identity of these extra bands.)
Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.
|Product Description||Host||Clonality||Application||Catalog# (PDF)|
|Anti-EpCAM Antibody (PE)||Rabbit||Monoclonal||FCM||10694-R028-P|
|Anti-EpCAM Antibody (APC)||Rabbit||Monoclonal||FCM||10694-R028-A|
|Anti-EpCAM Antibody (APC)||Mouse||Monoclonal||FCM||10694-MM06-A|
|Anti-EpCAM Antibody (FITC)||Mouse||Monoclonal||FCM||10694-MM06-F|
|Anti-EpCAM Antibody (PE)||Mouse||Monoclonal||FCM||10694-MM06-P|
|Anti-EpCAM Antibody (FITC)||Rabbit||Monoclonal||FCM||10694-R028-F|