Anti-EpCAM Antibody

Cat: 10694-MM07
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Anti-EpCAM Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-EpCAM Antibody
Validated applications
ELISA,ELISA(Cap)
Species reactivity
Reacts with: Human
Specificity
Human EpCAM
No cross-reactivity in ELISA with Human CD146 / MCAM Human CD171 / L1CAM Human OBCAM / OPCML Human TROP2 / TACSTD2
Immunogen
Recombinant Human EpCAM protein (Catalog#10694-H08H)
Preparation
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP1 (rh EpCAM; Catalog#10694-H08H; NP_002345.1; Met 1-Lys 265). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Source
Monoclonal Mouse IgG1 Clone #1B3H11A3
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EpCAM Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
ELISA(Cap) 1:250-1:2000 This antibody will detect Human EpCAM / TROP-1 / TACSTD1 in ELISA pair set (Catalog: # SEK10694). In a sandwich ELISA, it can be used as capture antibody when paired with (Catalog: # 10694-R028).

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EpCAM Antibody Alternative Names
Anti-DIAR5 Antibody;Anti-EGP-2 Antibody;Anti-EGP314 Antibody;Anti-EGP40 Antibody;Anti-ESA Antibody;Anti-HNPCC8 Antibody;Anti-KS1/4 Antibody;Anti-KSA Antibody;Anti-M4S1 Antibody;Anti-MIC18 Antibody;Anti-MK-1 Antibody;Anti-TACSTD1 Antibody;Anti-TROP-1 Antibody;Anti-TROP1 Antibody
EpCAM Background Information

Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
epithelial cell adhesion molecule
References
  • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
  • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
  • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
  • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA 90299-RP01
    Anti-EpCAM Antibody Rabbit Polyclonal WB,ELISA,IHC-P,IP 90299-T60
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA,IHC-P 80306-T24
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA 50591-RP01
    Anti-EpCAM Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),IHC-P 50591-R002
    Anti-EpCAM Antibody Rabbit Monoclonal ELISA(Cap) 50591-R052
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA,IHC-P 50591-RP02
    Anti-EpCAM Antibody Rabbit Monoclonal IHC-P 50591-R065
    Anti-EpCAM Antibody (PE) Rabbit Monoclonal FCM 10694-R028-P
    Anti-EpCAM Antibody Rabbit Polyclonal WB,ELISA 10694-RP02
    Anti-EpCAM Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),IHC-P,FCM,ICC/IF,IF,IP 10694-R028
    Anti-EpCAM Antibody (APC) Rabbit Monoclonal FCM 10694-R028-A
    Anti-EpCAM Antibody (APC) Mouse Monoclonal FCM 10694-MM06-A
    Anti-EpCAM Antibody Rabbit Polyclonal WB,ELISA,IP 10694-T52
    Anti-EpCAM Antibody Rabbit Polyclonal ELISA 10694-RP01
    Anti-EpCAM Antibody (FITC) Mouse Monoclonal FCM 10694-MM06-F
    Anti-EpCAM Antibody Mouse Monoclonal FCM 10694-MM06
    Anti-EpCAM Antibody (PE) Mouse Monoclonal FCM 10694-MM06-P
    Anti-EpCAM Antibody (FITC) Rabbit Monoclonal FCM 10694-R028-F
    Anti-EpCAM Antibody Mouse Monoclonal WB,IP 10694-MM05
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