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EpCAM / TROP-1 / TACSTD1 Antibody, Mouse MAb

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Human EpCAM Antibody Product Information
Immunogen:Recombinant Human EpCAM protein (Catalog#10694-H08H)
Clone ID:1B3H11A3
Ig Type:Mouse IgG1
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human EpCAM / TROP1 (rh EpCAM; Catalog#10694-H08H; NP_002345.1; Met 1-Lys 265). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Human EpCAM Antibody Usage Guide
Specificity:Human EpCAM / TROP1 / CD326
No cross-reactivity in WB and ELISA with
Human CD146 / MCAM
Human CD171 / L1CAM
Human OBCAM / OPCML
Human TROP2 / TACSTD2
Human cell lysate (293 cell line)
Application:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human EpCAM. The detection limit for Human EpCAM is 0.16 ng/well.

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other EpCAM Antibody Products
Reactivity: Human  
Application: ELISA  
    10694-RP01-100
    10694-RP01-200
    10694-RP01-400
    100 µg 
    200 µg 
     
    Add to Cart
    Reactivity: Human  
    Application: ELISA  WB  IHC-P  FCM  IF  IP  ICC/IF  
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    10694-R028-50
    10694-R028-100
    50 µg 
    100 µg 
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    Reactivity: Human  
    Application: ELISA  WB  
    • Slide 1
    10694-RP02-50
    10694-RP02-100
    10694-RP02-200
    50 µg 
    100 µg 
    200 µg 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-MM06-F-50
    10694-MM06-F-100
    50 Tests 
    100 Tests 
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    Reactivity: Human   
    Application: FCM  
    • Slide 1
    10694-MM06-P-50
    10694-MM06-P-100
    50 Tests 
    100 Tests 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-R028-A-100
    10694-R028-A-50
    100 Tests 
    50 Tests 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-MM06-200
    10694-MM06-100
    10694-MM06-50
    200 µg 
    100 µg 
    50 µg 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-MM06-A-100
    10694-MM06-A-50
    100 Tests 
    50 Tests 
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    Reactivity: Human  
    Application: WB  IP  
    • Slide 1
    • Slide 1
    10694-MM05-100
    10694-MM05-50
    10694-MM05-200
    100 µg 
    50 µg 
    200 µg 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-R028-P-100
    10694-R028-P-50
    100 Tests 
    50 Tests 
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    Reactivity: Human  
    Application: FCM  
    • Slide 1
    10694-R028-F-100
    10694-R028-F-50
    100 Tests 
    50 Tests 
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    Reactivity: Mouse  
    Application: ELISA  
      50591-RP01-100
      50591-RP01-200
      50591-RP01-400
      100 µg 
      200 µg 
       
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  IHC-P  
      • Slide 1
      • Slide 1
      • Slide 1
      50591-RP02-50
      50591-RP02-100
      50591-RP02-200
      50 µg 
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  WB  IHC-P  
      • Slide 1
      • Slide 1
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      50591-R002-50
      50591-R002-100
      50 µg 
      100 µg 
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      Reactivity: Mouse  
      Application: IHC-P  
      • Slide 1
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      50591-R065-100
      50591-R065-50
      100 µg 
      50 µg 
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      Reactivity: Rat  
      Application: ELISA  IHC-P  
      • Slide 1
      80306-T24-100
      80306-T24-200
      80306-T24-50
      100 µg 
      200 µg 
      50 µg 
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      Reactivity: Cynomolgus  
      Application: ELISA  WB  IHC-P  IP  
      • Slide 1
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      90299-T60-200
      90299-T60-100
      90299-T60-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Cynomolgus  
      Application: ELISA  
        90299-RP01-400
        90299-RP01-100
        90299-RP01-200
         
        100 µg 
        200 µg 
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        EpCAM/TROP-1/TACSTD1 Background

        Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

        Human EpCAM/TROP-1/TACSTD1 References
      • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
      • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
      • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
      • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
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        Catalog: 10694-MM07-50
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        All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
        Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"