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EpCAM/TROP-1/TACSTD1 Rabbit PAb

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    Human EpCAM Antibody Product Information
    Immunogen:Recombinant Human EpCAM protein (Catalog#10694-H08H)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:Produced in rabbits immunized with purified, recombinant Human EpCAM / TROP1 (rh EpCAM; Catalog#10694-H08H; NP_002345.1; Met 1-Lys265). Total IgG was purified by Protein A affinity chromatography.
    Other EpCAM Antibody Products
    Reactivity: Human  
    Application: ELISA  WB  IHC-P  FCM  IF  IP  ICC/IF  
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    10694-R028-50
    10694-R028-100
    50 µg 
    100 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10694-MM07-50
      10694-MM07-100
      10694-MM07-200
      50 µg 
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: ELISA  WB  
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      10694-RP02-50
      10694-RP02-100
      10694-RP02-200
      50 µg 
      100 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-MM06-F-50
      10694-MM06-F-100
      50 Tests 
      100 Tests 
      Add to Cart
      Reactivity: Human   
      Application: FCM  
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      10694-MM06-P-50
      10694-MM06-P-100
      50 Tests 
      100 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-R028-A-100
      10694-R028-A-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-MM06-200
      10694-MM06-100
      10694-MM06-50
      200 µg 
      100 µg 
      50 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-MM06-A-100
      10694-MM06-A-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: WB  IP  
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      10694-MM05-100
      10694-MM05-50
      10694-MM05-200
      100 µg 
      50 µg 
      200 µg 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-R028-P-100
      10694-R028-P-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Human  
      Application: FCM  
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      10694-R028-F-100
      10694-R028-F-50
      100 Tests 
      50 Tests 
      Add to Cart
      Reactivity: Mouse  
      Application: ELISA  
        50591-RP01-100
        50591-RP01-200
        50591-RP01-400
        100 µg 
        200 µg 
         
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  IHC-P  
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        50591-RP02-50
        50591-RP02-100
        50591-RP02-200
        50 µg 
        100 µg 
        200 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  WB  IHC-P  
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        50591-R002-50
        50591-R002-100
        50 µg 
        100 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: IHC-P  
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        50591-R065-100
        50591-R065-50
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Rat  
        Application: ELISA  IHC-P  
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        80306-T24-100
        80306-T24-200
        80306-T24-50
        100 µg 
        200 µg 
        50 µg 
        Add to Cart
        Reactivity: Cynomolgus  
        Application: ELISA  WB  IHC-P  IP  
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        90299-T60-200
        90299-T60-100
        90299-T60-50
        200 µg 
        100 µg 
        50 µg 
        Add to Cart
        Reactivity: Cynomolgus  
        Application: ELISA  
          90299-RP01-400
          90299-RP01-100
          90299-RP01-200
           
          100 µg 
          200 µg 
          Add to Cart
          EpCAM/TROP-1/TACSTD1 Background

          Epithelial Cell Adhesion Molecule (EpCAM), also known as GA733-2 antigen, is a type â… transmembrane glycoprotein composed of an extracellular domain with two EGF-Like repeats and a cystenin-rich region, a transmembrane domain and a cytoplasmic domain. It modulates cell adhesion and proliferation. Its overexpression has been detected in many epithelial tumours and has been associated with high stage, high grade and a worse survival in some tumour types. EpCAM has been shown to function as a calcium-independent homophilic cell adhesion molecule that does not exhibit any obvious relationship to the four known cell adhesion molecule superfamilies. However, recent insights have revealed that EpCAM participates in not only cell adhesion, but also in proliferation, migration and differentiation of cells. In addition, recent study revealed that EpCAM is the Wnt-beta-catenin signaling target gene and may be used to facilitate prognosis. It has oncogenic potential and is activated by release of its intracellular domain, which can signal into the cell nucleus by engagement of elements of the wnt pathway.

          Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

          Human EpCAM/TROP-1/TACSTD1 References
        • Brunner A, et al. (2008) EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. J Clin Pathol. 61(3):307-10.
        • Trzpis M, et al. (2008) EpCAM in morphogenesis. Front Biosci. 13: 5050-5.
        • Munz M, et al. (2009) The emerging role of EpCAM in cancer and stem cell signaling. Cancer Res. 69(14): 5627-9.
        • Carpenter G, et al. (2009) EpCAM: another surface-to-nucleus missile. Cancer Cell. 15(3): 165-6.
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          Size / Price
          Catalog: 10694-RP01-100
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          Datasheet & Documentation

          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"