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Escherichia coli Enoyl-ACP Reductase / FABI Antibody, Rabbit PAb, Antigen Affinity Purified

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    E. coli FABI Antibody Product Information
    Immunogen:Recombinant E.coli Enoyl-ACP Reductase / FABI protein (Catalog#30001-E07E)
    Clone ID:
    Ig Type:Rabbit IgG
    Concentration:
    Endotoxin:
    Formulation:0.2 μm filtered solution in PBS
    Preparation:Produced in rabbits immunized with purified, recombinant E.coli Enoyl-ACP Reductase / FABI (rE.coli Enoyl-ACP Reductase / FABI; Catalog#30001-E07E; NP_287908.1; Gly 2-Lys 262). Enoyl-ACP Reductase / FABI specific IgG was purified by E.coli Enoyl-ACP Reductase / FABI affinity chromatography.
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    Enoyl-ACP Reductase/FABI Background

    Enoyl-ACP reductase, also known as NADH-dependent enoyl-ACP reductase and FABI, is a cell inner membrane and peripheral membrane protein which belongs to the short-chain dehydrogenases/reductases (SDR) family and FabI subfamily. Microorganisms produce many kinds of antibiotics which function in an antagonistic capacity in nature where they have much competition. Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FABI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. The antibiotic diazaborine interferes with the activity by binding to the protein. FABI is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Various compounds have been reported as inhibitors of bacterial FabI-inhibitory compounds.

    E. coli Enoyl-ACP Reductase/FABI References
  • Miller, WH. et al., 2002, J Med Chem  45 (15):3246-56. 
  • Kitagawa, H. et al., 2007, Bioorg Med Chem  15 (2):1106-16.
  • Zheng, C.J. et al., 2007, Biochem Biophys Res Commun 362 (4):1107-12.
  • Lu,H. et al., 2008, Acc Chem Res 41 (1):11-20.
  • Zheng,CJ. et al., 2009, J Antimicrob Chemother 63 (5):949-53.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"