Endothelial Cell Markers

Protein Name	Alternative Names	BioChemical Class / Role	Products (Cat NO)
			Protein	Antibody	Gene cDNA clones
CD18	Integrin beta 2, ITGB2	The integrin beta chain beta 2. CD18 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1.
CD31	PECAM-1	A transmembrane glycoprotein expressed by endothelial cells, platelets, monocytes, neutrophils, and certain T cell subsets that plays a key role in removing aged neutrophils,  tissue regeneration, neutrophil recruitment in inflammatory responses, transendothelial migration of leukocytes, as well as in cardiovascular development. CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, other vascular tumors, and histiocytic malignancies.	10148-H02H 10148-H08H 10148-HCCH	10148-MM01 10148-MM02	HG10148-M
CD34		A single-pass transmembrane sialomucin protein, selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues. CD34 has been widely used as a stem and progenitor cell marker, and CD34 monoclonal antibodies are widely used to identify and isolate hemopoietic progenitors and to classify acute and chronic leukemias.	10103-H02H 10103-H08H		HG10103-M
CD36	SCARB3, gp4, FAT	An integral membrane protein belonging to the class B scavenger receptor family, found on the surface of many cell types in vertebrate animals. CD36 binds many ligands including oxidized low density lipoprotein, collagen, thrombospondin, oxidized phospholipids, long-chain fatty acids, and native lipoproteins, and thus is a multiple-function molecule. It may be involved in atherosclerosis, glucose intolerance, Alzheimer's disease, diabetes, cardiomyopathy and arterial hypertension.	10752-H08H		HG10752-M
CD112	Nectin-2, PVRL2	A type I transmembrane glycoprotein belonging to the Ig superfamily. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus. CD112 is a potential target for anti-allergic therapy.	10005-H02H 10005-H08H 10005-HCCH 50318-M08H	10005-MM01 10005-RP03 10005-RP04	HG10005-M
CD146	MCAM, MUC18	A Ca2+-independent cell adhesion molecule belonging to the immunoglobulin superfamily, involved in heterophilic cell interactions. CD146 triggers tyrosine phosphorylation of FYN and PTK2 and subsequently induced signal transduction, proteolysis, or immune recognition. CD146 is also expressed on metastatic lesions and advanced primary tumours, and thus has been suggested to play an important role in tumour progression and metastasis.	10115-H02H 10115-H08H	10115-MM03 10115-MM04 10115-MM05 10115-RP01 10115-RP02	HG10115-M
CD147	EMMPRIN, BSG	A transmembrane glycoprotein belonging to Ig superfamily, which induces the production and release of matrix metalloproteinases (MMP) in the surrounding mesenchymal cells and tumor cells, and thereby promotes invasion, metastasis, growth and survival of malignant cells. CD147 displays increased expression in many cancers, and it has been previously demonstrated to participate in cancer metastasis and progression.	10186-H02H 10186-H08H 10186-HCCH	10186-RP01	HG10186-M
CD150	SLAM, SLAMF1	Signaling lymphocytic activation molecule family member 1, expressed on thymocytes, memory T cells, B cells, platelets, natural killer T (NKT) cells, and mature dendritic cells. CD150 serves as a measles virus receptor and is involved in the regulation of differentiation and/or function of T helper (TH) 1 and TH2 cells, B lymphocytes, innate-like lymphocytes, dendritic cells and macrophages.	10837-H08H	10837-RP01 10837-RP02	HG10837-M
CL-K1/COLEC11	CL-K1-I, CL-K1-II, CL-K1-IIa, CL-K1-IIb, CLK1, DKFZp686N1868, MGC3279	CL-K1 is a member of the CDC2-like family of dual specificity protein kinases that phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing and release them into the nucleoplasm.			MG50195-M
DC-SIGNR	CLEC4M, CD299	A type II integral membrane protein that is regarded as a pathogen-recognition receptor involved in peripheral immune surveillance in liver. DC-SIGNR appears to selectively recognize and bind many viral surface glycoproteins containing high mannose N-linked oligosaccharides in a calcium-dependent manner, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, HCV E2, and human SARS coronavirus protein S, as well as the cellular adhesion protein ICAM3.	10559-H01H		HG10559-M
Endoglin	CD105	A membrane glycoprotein receptor for several TGF-beta superfamily members. It has a role in the development of the cardiovascular system and in vascular remodeling. In humans endoglin may be involved in the autosomal dominant disorder known as hereditary hemorrhagic telangiectasia type 1.	10149-H02H		HG10149-M
ESAM		Endothelial cell-selective adhesion molecule, belonging to the JAM family of Ig superfamily. ESAM is specifically expressed at endothelial tight junctions and on activated platelets, and performs homophilic adhesion activity. It also participates in the migration of neutrophils through the vessel wall. ESAM-deficient mice were described with lowered angiogenic potential, and overexpression of ESAM is closely associated with certain tumor growth and metastasis.	10187-H02H 10187-HCCH		HG10187-M
E-Selectin	CD62e, ELAM-1, ELAM1, ELAM, SELE, RP1-117P20.2, ESEL, LECAM2	An inducible adhesion molecule that supports rolling and stable arrest of leukocytes on activated vascular endothelium, and can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. In addition, E-selectin appears to be involved in the pathogenesis of atherosclerosis.	10335-H03H 10335-H08H		HG10335-M
ICAM-1	CD54, BB2, P3.58	Inter-Cellular Adhesion Molecule 1, a type of intercellular adhesion molecule constitutely present in low concentrations in the membranes of leukocytes and endothelial cells. ICAM-1 is well known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. It also becomes known for its affinity for Plasmodium falciparum-infected erythrocytes (PFIE), providing more of a role in infectious disease.	10346-H03H 10346-H08H 10346-HCCH		HG10346-M
ICAM-2	CD102	Inter-Cellular Adhesion Molecule 2, mainly expressed on vascular endothelial and hematopoietic cells. Interactions of ICAM-2 and the integrin receptors mediate cell adhesion in a wide range of lymphocyte, monocyte, natural killer cell, and granulocytewith other cells, and play important roles in many adhesion-dependent immune and inflammation responses, such as T cell aggregation, NK-cell cytotoxicity and migration, lymphocyte recirculation, etc.	10332-H03H		HG10332-M
IL-13RA1	IL13RA1, CD213a1	A subunit of the IL-13 receptor which forms a functional receptor complex for IL-13 with IL-4 receptor alpha, transducing an IL13-dependent proliferative signal. IL-13RA1 binds IL-13 with a low affinity.	10943-H03H 10943-H08H 50088-M03H 50088-M08H		HG10943-M MG50088-M
IL-1R1	IL-1R-alpha, CD121a	Interleukin 1 receptor, type I, which is an 80 kDa transmembrane protein expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1R1 appears to mediate all the known IL-1 biological functions.	10126-H02H 10126-H08H	10126-RP01 10126-RP02	HG10126-M
Integrin alpha 4	CD49d	Integrin alpha 4 belongs to the integrin alpha chain family of proteins, and forms heterodimeric complex with either beta 1 chain or beta 7 chain.			MG50049-M
LYVE-1	XLKD1	A type I integral membrane glycoprotein that acts as a receptor and binds to both soluble and immobilized hyaluronan. LYVE-1 may function in lymphatic hyaluronan transport and have a role in tumor metastasis.			HG10237-M MG50065-M
Podoplanin	PDPN	A type-I integral membrane glycoprotein with diverse distribution in human tissues. Mouse PDPN is detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. PDPN is probably required for normal lung cell proliferation and alveolus formation at birth.	50256-M03H		HG11065-M MG50256-M
Tie2	Tie-2, TEK, CD202b	A member of the receptor tyrosine kinase superfamily, expressed predominantly on endothelial and hematopoietic progenitor cells. Tie2 is essential for blood vessel formation and maintenance. It binds to angiopoietin-1 with high-affinity and induces the signaling pathway of both cell migration and cell survival via the related mediator such as GRB2 and SH-PTP2. Deficiency in TI2 gene is associated with inherited venous malformations.	10700-H03H 10700-H08H		HG10700-M
TNFR1	CD120a, TNFRSF1A	A type I transmembrane protein which is widely expressed. TNFR1 serves as a receptor for TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha, and is involved in caspases mediating apoptosis. It can also activate the transcription factor NF-kB, and functions as a regulator of inflammation. Germline mutations of the extracellular domains of TNFR1 are found to be associated with the human genetic disorder called periodic fever syndrome.	10872-H03H		HG10872-M
TNFR2	CD120b, TNFRSF1B	A member to the TNF-receptor superfamily. TNFR2 inhibits TNF-alpha action by competing with cell surface receptors in binding TNF-alpha, thereby blocking its biologic effects. Knockout studies in mice suggest a role of TNFR2 in protecting neurons from apoptosis by stimulating antioxidative pathways.	10872-H03H		HG10872-M
TRAIL R1	TNFRSF10A, CD261	A member of the tumor necrosis factor (TNF) receptor superfamily. TRAILR2 is activated by TNF-related apoptosis inducing ligand (TNFSF10/TRAIL), and transduces cell death signal and induces cell apoptosis.	10408-H03H		HG10465-M
TRAIL R2	TNFRSF10B, CD262	A member of the tumor necrosis factor (TNF) receptor superfamily. TRAILR2 can be activated by TNF-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal.	10465-H03H 10465-H08H		HG10113-M
VCAM-1	CD106	Vascular cell adhesion molecule-1 (VCAM-1) mediates the adhesion of lymphocytes, basophils, eosinophils, and monocytes to vascular endothelium. It also functions in leukocyte-endothelial cell signal transduction, and it may play a role in the development of atherosclerosis and rheumatoid arthritis.			HG10433-M
VE-Cadherin	CD144, CDH5	A classical cadherin from the cadherin superfamily with calcium-dependent activity. VE-Cadherin is required for maintaining a restrictive endothelial barrier and indispensable for proper vascular development. It also has a role in maintaining newly formed vessels.	50192-M08H		HG10433-M MG50192-M
VEGFR1/Flt1		Vascular endothelial growth factor (VEGF) receptor 1			HG10012-M
VEGFR2	KDR, CD309, Flk1	The receptor for VEGF and VEGFC. VEGFR2 is an early marker for endothelial cell progenitors, whose expression is restricted to endothelial cells in vivo. The adaptor protein SHB has been shown to interact with VEGFR2 in receptor tyrosine kinase signaling. In addition, VEGFR2 is able to interact with HIV-1 extracellular Tat protein upon VEGF activation, and seems to enhance angiogenesis in Kaposi's sarcoma lesions.	10012-H02H		HG10012-M
VEGFR3/FLT-4	FLT41, LMPH1A, PCL	VEGFR3 (FLT-4), together with the other two members VEGFR1 (FLT-1) and VEGF R2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs).	10806-H02H 10806-H08H	10806-MM02 10806-MM03 10806-RP01 10806-RP04	HG10806-M
VG5Q	AGGF1	A potent angiogenic factor that contains a forkhead-associated domain and a G-patch domain.			HG10162-M