All Endoglin / CD105 reagents are produced in house and quality controlled, including 28 Endoglin / CD105 Antibody, 4 Endoglin / CD105 ELISA, 39 Endoglin / CD105 Gene, 3 Endoglin / CD105 Lysate, 3 Endoglin / CD105 Protein, 3 Endoglin / CD105 qPCR. All Endoglin / CD105 reagents are ready to use.
Recombinant Endoglin / CD105 proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc.
Endoglin / CD105antibodies are validated with different applications, which are ELISA, ELISA(Det), ELISA(Cap), IHC-P, ICC/IF, IF, FCM, WB.
Endoglin / CD105cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Endoglin / CD105 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Endoglin / CD105ELISA Kit are quality controlled by 8 internation QC standard which guarantee every ELISA Kit with high quality.
Endoglin, also known as CD105, is a type I homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.