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Endoglin / CD105 / ENG Antibody, Rabbit MAb

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Mouse CD105/ENG Antibody Product Information
Immunogen:Recombinant Mouse Endoglin / CD105 / ENG Protein (Catalog#50407-M08H)
Clone ID:001
Ig Type:Rabbit IgG
Formulation:0.2 μm filtered solution in PBS with 5% trehalose
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Endoglin / CD105 / ENG (rM Endoglin / CD105 / ENG; Catalog#50407-M08H; NP_031958.2; Met 1-Gly 580).
Mouse CD105/ENG Antibody Usage Guide
Specificity:Mouse Endoglin / CD105 / ENG
No cross-reactivity in ELISA with
Human CD105
Application:WB, ELISA, FCM

WB: 10-20 μg/mL

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse ENG. The detection limit for Mouse ENG is approximately 0.00245 ng/well.

FCM: 0.5-2 μg/Test

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse CD105/ENG Antibody WB Application Image
Mouse CD105/ENG Antibody FC Application Image
Endoglin / CD105  Antibody, Rabbit MAb, Flow Cytometry
[Click to enlarge image]
Flow cytometric analysis of Mouse ENG(CD105) expression on bEnd.3 cells. Cells were stained with purified anti-Mouse ENG(CD105), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other CD105/ENG Antibody Products
Endoglin/CD105  Background

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

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Catalog: 50407-R001-100
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50 µg
100 µg
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