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Endoglin / CD105 Antibody (FITC), Mouse MAb

  • Endoglin / CD105 Antibody (FITC), Mouse MAb, Flow cytometric
  • Endoglin / CD105 Antibody (FITC), Mouse MAb, Flow cytometric
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Human CD105/ENG Antibody Product Information
Immunogen:Recombinant Human CD105 protein (Catalog#10149-H08H)
Clone ID:4A3G3D3
Ig Type:Mouse IgG2b
Concentration:10 μl/Test, 0.1 mg/ml
Endotoxin:
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Endoglin / CD105 (rh CD105; Catalog#10149-H08H; Met 1-Gly 586; NP_001108225.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography and conjugated with FITC under optimum conditions, the unreacted FITC was removed .
Human CD105/ENG Antibody FC Application Image
Endoglin / CD105 Antibody (FITC), Mouse MAb, Flow cytometric
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Caption:
Flow cytometric analysis of CD105 expression on human HeLa cells. HeLa cells were stained with FITC Mouse anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.
Endoglin / CD105 Antibody (FITC), Mouse MAb, Flow cytometric
[Click to enlarge image]
Caption:
Flow cytometric analysis of CD105 expression on human HUVEC cells. HUVEC cells (Human umbilical vein endothelial cells) were stained with FITC Mouse anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.
Other CD105/ENG Antibody Products
Endoglin/CD105  Background

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

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