Anti-Endoglin / CD105 Antibody (FITC)

Cat: 10149-R103F
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All Endoglin / CD105 Reagents
Anti-Endoglin / CD105 Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-Endoglin / CD105 Antibody (FITC)
Validated applications
FCM
Species reactivity
Reacts with: Human
Specificity
Human Endoglin / CD105
No cross-reactivity in ELISA with Mouse ENG/CD105
Immunogen
Recombinant Human CD105 protein (Catalog#10149-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Endoglin / CD105 (rh CD105; Catalog#10149-H08H; Met 1-Gly 586; NP_001108225.1) and conjugated with FITC under optimum conditions, the unreacted FITC was removed .
Source
Monoclonal Rabbit IgG Clone #103
Purification
Protein A
Formulation
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Conjugate
FITC
Concentration
10 μl/Test, 0.1 mg/ml
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-Endoglin / CD105 Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Endoglin / CD105 Antibody (FITC) (Rabbit Monoclonal antibody) Images
Human Endoglin/CD105  Flow Cytometry (FC) 5374
Flow cytometric analysis of CD105 expression on human HUVEC cells. HUVEC cells (Human umbilical vein endothelial cells) were stained with FITC Rabbit anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.
Human Endoglin/CD105  Flow Cytometry (FC) 5376
Flow cytometric analysis of CD105 expression on human HeLa cells. HeLa cells were stained with FITC Rabbit anti-Human CD105 antibody (solid line fluorescence histogram) or a negative control at a matching concentration; dashed line histogram) antibody. Flow cytometric fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable cells.
Anti-Endoglin / CD105 Antibody (FITC) Alternative Names
Anti-END Antibody;Anti-HHT1 Antibody;Anti-ORW1 Antibody
Endoglin / CD105 Background Information

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

Full Name
endoglin
References
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal WB,ELISA,FCM 50407-R001
    Anti-Endoglin / CD105 Antibody (FITC) Rabbit Monoclonal FCM 50407-R001-F
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA(Cap) 50407-R029
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA,IHC-P 50407-RP02
    Anti-Endoglin / CD105 Antibody (APC) Rabbit Monoclonal FCM 50407-R001-A
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA(Det) 50407-R028
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA 50407-RP01
    Anti-Endoglin / CD105 Antibody (PE) Rabbit Monoclonal FCM 50407-R001-P
    Anti-Endoglin / CD105 Antibody (APC) Mouse Monoclonal FCM 10149-MM13-A
    Anti-Endoglin / CD105 Antibody (FITC) Mouse Monoclonal FCM 10149-MM11-F
    Anti-Endoglin / CD105 Antibody (FITC) Mouse Monoclonal FCM 10149-MM13-F
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA 10149-MM12
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 10149-R103
    Anti-Endoglin / CD105 Antibody (PE) Mouse Monoclonal FCM 10149-MM13-P
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal WB,ICC/IF,IF 100558-T34
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 10149-T26
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA(Cap) 10149-MM05
    Anti-Endoglin / CD105 Antibody (PE) Rabbit Monoclonal FCM 10149-R103-P
    Anti-Endoglin / CD105 Antibody (PerCP) Rabbit Monoclonal FCM 10149-R103-C
    Anti-Endoglin / CD105 Antibody (FITC) Rabbit Monoclonal FCM 10149-R103-F
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal IHC-P 100088-RP02
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA 10149-RP01
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA 10149-R001
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10149-MM11
    Anti-Endoglin / CD105 Antibody (APC) Rabbit Monoclonal FCM 10149-R103-A
    Anti-Endoglin / CD105 Antibody (PerCP) Mouse Monoclonal FCM 10149-MM13-C
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal FCM 10149-MM13
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal WB,ELISA 10149-RP02
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