Anti-Endoglin / CD105 Antibody

Cat: 50407-RP02
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All Endoglin / CD105 Reagents
Anti-Endoglin / CD105 Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-Endoglin / CD105 Antibody
Validated applications
ELISA,IHC-P
Species reactivity
Reacts with: Mouse
Specificity
Mouse Endoglin / CD105
Immunogen
Recombinant Mouse CD105 protein (Catalog#50407-M08H)
Preparation
Produced in rabbits immunized with purified, recombinant Mouse ENG / CD105 extracellular domain (rM Endoglin; Catalog#50407-M08H; NP_031958.2; Met 1-Gly 580). ENG / CD105 specific IgG was purified by Mouse ENG / CD105 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Endoglin / CD105 Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Endoglin / CD105 Antibody (Rabbit Polyclonal antibody) Images
Mouse Endoglin/CD105  Immunohistochemistry(IHC) 3310
Immunochemical staining of mouse ENG in mouse uterus with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to vascular endothelial cells. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Mouse Endoglin/CD105  Immunohistochemistry(IHC) 3311
Immunochemical staining of mouse ENG in mouse liver with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections). Positive staining was localized to vascular endothelial cells. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Anti-Endoglin / CD105 Antibody Alternative Names
Anti-AI528660 Antibody;Anti-AI662476 Antibody;Anti-CD105 Antibody;Anti-Endo Antibody;Anti-S-endoglin Antibody
Endoglin / CD105 Background Information

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

Full Name
endoglin
References
  • Bellon T., et al.,(1993), Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions. Eur. J. Immunol. 23:2340-2345.
  • Humphray S.J., et al., (2004), DNA sequence and analysis of human chromosome 9.Nature 429:369-374.
  • Gougos A., et al.,(1990), Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.J. Biol. Chem. 265:8361-8364.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Endoglin / CD105 Antibody (PE) Rabbit Monoclonal FCM 50407-R001-P
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA 50407-RP01
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA(Det) 50407-R028
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA(Cap) 50407-R029
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal WB,ELISA,FCM 50407-R001
    Anti-Endoglin / CD105 Antibody (FITC) Rabbit Monoclonal FCM 50407-R001-F
    Anti-Endoglin / CD105 Antibody (APC) Rabbit Monoclonal FCM 50407-R001-A
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA 10149-MM12
    Anti-Endoglin / CD105 Antibody (PE) Rabbit Monoclonal FCM 10149-R103-P
    Anti-Endoglin / CD105 Antibody (FITC) Mouse Monoclonal FCM 10149-MM13-F
    Anti-Endoglin / CD105 Antibody (PE) Mouse Monoclonal FCM 10149-MM13-P
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal WB,ICC/IF,IF 100558-T34
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA,IHC-P,ICC/IF,IF 10149-T26
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal FCM,ICC/IF,IF 10149-R103
    Anti-Endoglin / CD105 Antibody (FITC) Mouse Monoclonal FCM 10149-MM11-F
    Anti-Endoglin / CD105 Antibody (PerCP) Rabbit Monoclonal FCM 10149-R103-C
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal ELISA 10149-RP01
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA(Cap) 10149-MM05
    Anti-Endoglin / CD105 Antibody (FITC) Rabbit Monoclonal FCM 10149-R103-F
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal IHC-P 100088-RP02
    Anti-Endoglin / CD105 Antibody (APC) Rabbit Monoclonal FCM 10149-R103-A
    Anti-Endoglin / CD105 Antibody (PerCP) Mouse Monoclonal FCM 10149-MM13-C
    Anti-Endoglin / CD105 Antibody (APC) Mouse Monoclonal FCM 10149-MM13-A
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal ELISA,ELISA(Det) 10149-MM11
    Anti-Endoglin / CD105 Antibody Rabbit Monoclonal ELISA 10149-R001
    Anti-Endoglin / CD105 Antibody Mouse Monoclonal FCM 10149-MM13
    Anti-Endoglin / CD105 Antibody Rabbit Polyclonal WB,ELISA 10149-RP02
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