Elafin (PI3, WFDC14)

Elafin is neutrophil and pancreatic elastase-specific inhibitor of skin. Elafin may prevent elastase-mediated tissue proteolysis.

Elafin (PI3, WFDC14) Related Areas

Enzyme>>Protease & Regulator>>Other Proteases & Regulators>>PI3/Elafin/WFDC14

Elafin (PI3, WFDC14) Alternative Names

PI3, Elafin,WFDC14, ESI, MGC13613, SKALP, WAP3, cementoin [Homo sapiens]

Summaries for Elafin (PI3, WFDC14)

Entrez Gene summary for Elafin (PI3, WFDC14):

PI3 gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. PI3 gene belongs to the centromeric cluster. Expression of PI3 gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2008]

OMIM - description for Elafin (PI3, WFDC14):

PI3 is a serine protease inhibitor that plays a major role as an antiinflammatory mediator at mucosal surfaces. In addition, PI3 has antibacterial activity against gram-positive and gram-negative bacterial and fungal pathogens (summary by Ghosh et al., 2009).

Wikipedia summary for Elafin (PI3, WFDC14):

Elafin, also known as peptidase inhibitor 3 or skin-derived antileukoprotease (SKALP), is a protein that in humans is encoded by the PI3 gene.

Human Elafin (PI3, WFDC14) Protein General Information

 

• Protein names: Elafin
• Sequence length: 117 AA.
• Domain: Consists of two domains: the transglutaminase substrate domain (cementoin moiety) and the elastase inhibitor domain. The transglutaminase substrate domain serves as an anchor to localize elafin covalently to specific sites on extracellular matrix proteins.
• Sequence similarities: Contains 1 WAP domain.
• Subcellular location: Secreted.

General information above from UniProt

Function for Elafin (PI3, WFDC14) Protein

UniProtKB:

Elafin is neutrophil and pancreatic elastase-specific inhibitor of skin. Elafin may prevent elastase-mediated tissue proteolysis.

Genatlas:

• Elafin is involved in the regulation of inflammation and in protection against tissue damage
• Elafin regulates proteolytic enzymes during menstruation and contributes to the innate defense against uterine infection