All ETS1 reagents are produced in house and quality controlled, including 1 ETS1 Antibody, 15 ETS1 Gene, 1 ETS1 qPCR. All ETS1 reagents are ready to use.
ETS1 antibodies are validated with different applications, which are ICC/IF, IF.
ETS1 cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ETS1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
The ETS transcription factors regulate expression of genes involved in normal cell development, proliferation, differentiation, angiogenesis, and apoptosis, consisting of 28 family members in humans. Dysregulation of these transcription factors facilitates cell proliferation in cancers, and several members participate in invasion and metastasis by activating gene transcription. ETS1 and ETS2 are the founding members of the ETS family and regulate transcription by binding to ETS sequences. They are both involved in oncogenesis and tumor suppression depending on the biological situations used. ETS1 could be used as a novel marker of poor response to DDP and a potential therapeutic target for TNBC chemotherapy. the ETS1 transcription factor was found to enhance the VEGFA/VEGFR2 expression by directly binding to their promoters and facilitated FGF9-dependent elevation of VEGF-signaling which augmented the metastatic potential of Ovarian cancer (OC) cells.