Text Size:AAA
Related Family Members
Protein Wiki by Initials

ESM1

ESM1 Protein & Antibody

Entrez Gene Summary for ESM1


ESM1 gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for ESM1 gene. [provided by RefSeq, Oct 2008]

OMIM-Description for ESM1


.zh=ESM1


Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene.
ESM1 gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.

ESM1 Alternative Names

endocan, [homo-sapiens]
Endocan,ESM-1, [human]
0610042H23Rik,AV004503,ESM-1, [mouse]
ESM-1,AV004503,0610042H23Rik, [mus-musculus]

ESM1 Related Products

ESM1 Proteins

Product nameProduct name
Mouse ESM1 / Endocan Protein (His Tag)Human ESM1 / Endocan Protein (His Tag)

ESM1 Antibodies

Product nameProduct name

ESM1 cDNA Clones

Product nameProduct name
Mouse ESM1 natural ORF mammalian expression plasmidHuman ESM1 ORF mammalian expression plasmid, C-Flag tagMouse ESM1 ORF mammalian expression plasmid, C-HA tagMouse ESM1 ORF mammalian expression plasmid, C-GFPSpark tagHuman ESM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tagMouse ESM1 ORF mammalian expression plasmid, C-His tagMouse ESM1 ORF mammalian expression plasmid, N-Flag tagMouse ESM1 ORF mammalian expression plasmid, C-Flag tagHuman ESM1 ORF mammalian expression plasmid, N-Myc tagMouse ESM1 ORF mammalian expression plasmid, C-OFPSpark / RFP tagMouse ESM1 ORF mammalian expression plasmid, N-HA tagHuman ESM1 ORF mammalian expression plasmid, N-His tagHuman ESM1 Gene cDNA clone plasmidHuman ESM1 ORF mammalian expression plasmid, C-Myc tagMouse ESM1 ORF mammalian expression plasmid, N-Myc tagMouse ESM1 Gene cDNA clone plasmidMouse ESM1 ORF mammalian expression plasmid, C-Myc tagMouse ESM1 ORF mammalian expression plasmid, N-His tagHuman ESM1 ORF mammalian expression plasmid, C-GFPSpark tagHuman ESM1 ORF mammalian expression plasmid, N-HA tagHuman ESM1 ORF mammalian expression plasmid, C-HA tagHuman ESM1 ORF mammalian expression plasmid, N-Flag tagHuman ESM1 natural ORF mammalian expression plasmidHuman ESM1 ORF mammalian expression plasmid, C-His tag

ESM1 ELISA

Product nameProduct name
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"