ESM1

ESM1 is a secreted protein which is produced by adipocytes. It has been noticed that ESM1 may play some role in obesity-associated vascular disease since circulating ESM-1 levels are reduced in the overweight and obese. ESM1 is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. Recently, ESM1 has been described as a specific biomarker of tip cells during neoangiogenesis. Its expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF or FGF-2. In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against ESM1.

ESM1 Alternative Names

Endocan, ESM-1 [Homo sapiens]

0610042H23Rik, AV004503, ESM-1 [Mus musculus]

Summaries for ESM1

Entrez Gene summary for ESM1:

ESM1 gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of ESM1 gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. Two transcript variants encoding different isoforms have been found for ESM1 gene. [provided by RefSeq, Oct 2008]

Wikipedia summary for ESM1:

Endothelial cell-specific molecule 1 is a protein that in humans is encoded by the ESM1 gene.
ESM1 gene encodes a secreted protein which is mainly expressed in the endothelial cells in human lung and kidney tissues. The expression of this gene is regulated by cytokines, suggesting that it may play a role in endothelium-dependent pathological disorders. The transcript contains multiple polyadenylation and mRNA instability signals. The ESM-1 gene product is also called endocan since 2001, when it was characterized as a dermatan sulfate proteoglycan by Bechard et al. Recently, endocan / ESM-1 has been described as a specific biomarker of tip cells during neoangiogenesis by independent teams. Endocan expression has been shown to be increase in presence of pro-angiogenic growth factors such as VEGF (vascular endothelial growth factor) or FGF-2 (fibroblast growth factor 2). In hypervascularized cancers, overexpression of endocan has been detected by immunohistochemistry using monoclonal antibodies against endocan / ESM-1.

Human ESM1 Protein General Information

 

• Protein names: Endothelial cell-specific molecule 1
  Short name=ESM1
• Sequence length: 184 AA.
• Domain: Signal
• Sequence similarities: Contains 1 IGFBP N-terminal domain.
• Post-translational modification: May contain intrachain disulfide bonds.
  O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
• Subunit structure: Monomer.
• Subcellular location: Secreted.
• Tissue specificity: Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.
• Induction: By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-4.

General information above from UniProt

Function for ESM1 Protein

UniProtKB:

ESM1 may have potent implications in lung endothelial cell-leukocyte interactions.

Genatlas:

• ESM1 is chondroitin sulfate/dermatan sulfate proteoglycan promoting hepatocyte growth factor/scatter factor mitogenic activity