Endothelial Cell Adhesion Molecule Protein & Antibody (ESAM)

Endothelial Cell-Selective Adhesion Molecule

Endothelial Cell Adhesion Molecule Products

Endothelial Cell Adhesion Molecule Protein, Recombinant

Molecule	Species	Description	Cat. No
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H02H
ESAM	Human	ESAM/Fc Protein, Recombinant	10187-H08H
ESAM	Human	ESAM Protein, Recombinant	10187-HCCH
ESAM	Mouse	ESAM Protein, Recombinant	50977-M08H
ESAM	Rat	ESAM Protein, Recombinant	80241-R02H

Endothelial Cell Adhesion Molecule Antibody

Molecule	Application	Description	Cat. No
Human ESAM	WB, ELISA	ESAM Antibody, Mouse MAb	10187-MM01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody	10187-RP01
Human ESAM	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10187-RP02

Endothelial Cell Adhesion Molecule cDNA Clone

Molecule	Species	Description	Cat. No
ESAM	Human	Homo sapiens ESAM cDNA Clone(NM_138961.2)	HG10187-M
ESAM	Mouse	ESAM cDNA Clone / ORF Clone	MG50977-G
ESAM	Rat	ESAM cDNA Clone / ORF Clone	RG80241-G

Endothelial Cell Adhesion Molecule Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>ESAM

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>ESAM

Immunology>>Adhesion Molecule>> Cell Adhesion Molecule (IgSF CAM)>>ESAM

Endothelial Cell Adhesion Molecule Alternative Names

ESAM, W117m [Homo sapiens]

Esam, Esam1, W117m, 2310008D05Rik [Mus musculus]

Endothelial Cell Adhesion Molecule Background

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Endothelial Cell Adhesion Molecule Related Studies

1. Ishida T, et al. (2003) Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem. 278(36): 34598-604.
2. Wegmann F, et al. (2004) Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Exp Cell Res. 300(1): 121-33.
3. Wegmann F, et al. (2006) ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med. 203(7): 1671-7.
4. Hara T, et al. (2009) Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy. Microvasc Res. 77(3): 348-55.
5. Cangara HM, et al. (2010) Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis. Microvasc Res. 80(1): 133-41.