Anti-ESAM Antibody

Cat: 10187-RP02
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All ESAM Reagents
Anti-ESAM Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-ESAM Antibody
Validated applications
Species reactivity
Reacts with: Human
Human ESAM
Recombinant Human ESAM protein (Catalog#10187-H08H)
Produced in rabbits immunized with purified, recombinant Human ESAM extracellular domain (rh ESAM; Catalog#10187-H08H; NP_620411.2; Met 1-Ala 248). ESAM specific IgG was purified by human ESAM affinity chromatography.
Polyclonal Rabbit IgG
Protein A & Antigen Affinity
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ESAM Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
WB 1:500-1:1000  
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ESAM Antibody (Rabbit Polyclonal antibody) Images
Human Endothelial Cell Adhesion Molecule Western blot (WB) 13138

Anti-ESAM rabbit polyclonal antibody at 1:500 dilution

Lane A: HepG2 Membrane Lysate

Lysates/proteins at 20 μg per lane.


Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:41 kDa

Observed band size:37 kDa

Anti-ESAM Antibody Alternative Names
Anti-W117m Antibody
ESAM Background Information

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Full Name
endothelial cell adhesion molecule
  • Ishida T, et al. (2003) Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem. 278(36): 34598-604.
  • Wegmann F, et al. (2004) Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Exp Cell Res. 300(1): 121-33.
  • Wegmann F, et al. (2006) ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med. 203(7): 1671-7.
  • Hara T, et al. (2009) Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy. Microvasc Res. 77(3): 348-55.
  • Cangara HM, et al. (2010) Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis. Microvasc Res. 80(1): 133-41.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ESAM Antibody Rabbit Monoclonal ELISA 50977-R110
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 50977-RP01
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 50977-T16
    Anti-ESAM Antibody (PE) Rabbit Monoclonal FCM 10187-R113-P
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 10187-RP01
    Anti-ESAM Antibody Rabbit Polyclonal IHC-P 101677-T08
    Anti-ESAM Antibody (FITC) Rabbit Monoclonal FCM 10187-R113-F
    Anti-ESAM Antibody Rabbit Monoclonal ELISA 10187-R202
    Anti-ESAM Antibody Rabbit Monoclonal FCM 10187-R113
    Anti-ESAM Antibody Mouse Monoclonal ELISA 10187-MM01
    Anti-ESAM Antibody (APC) Rabbit Monoclonal FCM 10187-R113-A
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