Anti-ESAM Antibody (FITC)

Cat: 10187-R113-F
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All ESAM Reagents
Anti-ESAM Antibody (FITC) (Rabbit Monoclonal antibody) General Information
Product name
Anti-ESAM Antibody (FITC)
Validated applications
Species reactivity
Reacts with: Human
Human ESAM
Recombinant Human ESAM protein (Catalog#10187-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human ESAM (rh ESAM; Catalog#10187-H08H; NP_620411.2; Met 1-Ala 248) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Monoclonal Rabbit IgG Clone #113
Protein A
Aqueous solution containing 0.5% BSA and 0.09% sodium azide
10 μl/Test, 0.1 mg/ml
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
Anti-ESAM Antibody (FITC) (Rabbit Monoclonal antibody) Validated Applications

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ESAM Antibody (FITC) (Rabbit Monoclonal antibody) Images
Human Endothelial Cell Adhesion Molecule Flow Cytometry (FC) 2594
Profile of anti-ESAM reactivity on HUVEC cells analyzed by flow cytometry.
Anti-ESAM Antibody (FITC) Alternative Names
Anti-W117m Antibody
ESAM Background Information

Endothelial cell-selective adhesion molecule (ESAM) is a member of JAM family of immunoglobulin superfamily and consists of one V-type and one C2-type immunoglobulin domain, as well as a hydrophobic signal sequence, a single transmembrane region, and a cytoplasmic domain. It is specifically expressed at endothelial tight junctions and on activated platelets. ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. Previous studies have indicated that ESAM regulates angiogenesis in the primary tumor growth and endothelial permeability. It suggest that ESAM has a redundant functional role in physiological angiogenesis but serves a unique and essential role in pathological angiogenic processes such as tumor growth.

Full Name
endothelial cell adhesion molecule
  • Ishida T, et al. (2003) Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. J Biol Chem. 278(36): 34598-604.
  • Wegmann F, et al. (2004) Endothelial adhesion molecule ESAM binds directly to the multidomain adaptor MAGI-1 and recruits it to cell contacts. Exp Cell Res. 300(1): 121-33.
  • Wegmann F, et al. (2006) ESAM supports neutrophil extravasation, activation of Rho, and VEGF-induced vascular permeability. J Exp Med. 203(7): 1671-7.
  • Hara T, et al. (2009) Endothelial cell-selective adhesion molecule regulates albuminuria in diabetic nephropathy. Microvasc Res. 77(3): 348-55.
  • Cangara HM, et al. (2010) Role of endothelial cell-selective adhesion molecule in hematogeneous metastasis. Microvasc Res. 80(1): 133-41.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ESAM Antibody Rabbit Monoclonal ELISA 50977-R110
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 50977-RP01
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 50977-T16
    Anti-ESAM Antibody (PE) Rabbit Monoclonal FCM 10187-R113-P
    Anti-ESAM Antibody Rabbit Polyclonal ELISA 10187-RP01
    Anti-ESAM Antibody Rabbit Polyclonal IHC-P 101677-T08
    Anti-ESAM Antibody Rabbit Monoclonal ELISA 10187-R202
    Anti-ESAM Antibody Rabbit Monoclonal FCM 10187-R113
    Anti-ESAM Antibody Mouse Monoclonal ELISA 10187-MM01
    Anti-ESAM Antibody (APC) Rabbit Monoclonal FCM 10187-R113-A
    Anti-ESAM Antibody Rabbit Polyclonal WB,ELISA 10187-RP02
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