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ERP72 (PDIA4)

ERP72, also known as PDIA4, is an endoplasmic reticulum luminal protein which belongs to the protein disulfide isomerase family. ERP72 is a stress protein and participates in the catalysis of protein-S-S-bond rearrangement. Both of PDIA4 and PDIA3 function as proteases, protein disulfide isomerases, phospholipases or an arrangement of these. ERP72 compose part of a large chaperone multiprotein complex comprising CABP1, DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

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ERP72 (PDIA4) Related Products

ERP72 Proteins

ERP72 Antibodies

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ERP72 ELISA Pair sets

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ERP72 cDNA Clones

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ERP72 (PDIA4) Related Areas

 

ERP72 (PDIA4) Related Pathways

ERP72 (PDIA4) Alternative Names

ERP70, ERP72, ERp-72, ER protein 70, ER protein 72, endoplasmic reticulum resident protein 70, endoplasmic reticulum resident protein 72, protein disulfide isomerase related protein (calcium-binding protein, intestinal-related), protein disulfide isomerase-associated 4, protein disulfide-isomerase A4 [Homo sapiens]

AI987846, Cai, ERp-72, Erp72, ER protein 72, calcium binding protein, intestinal, endoplasmic reticulum protein 72, endoplasmic reticulum resident protein 72, protein disulfide-isomerase A4 [Mus musculus]

Summaries for ERP72 (PDIA4)

Human ERP72 (PDIA4) Protein General Information

 

Protein names

Endoplasmic reticulum resident protein 72, Short name=ERp72

Sequence length

645 AA.

Caution

ERP72 was originally thought to be a deoxycytidine kinase.

Sequence similarities:

ERP72 belongs to the protein disulfide isomerase family. ERP72 contains 3 thioredoxin domains.

Catalytic activity:

ERP72 catalyzes the rearrangement of -S-S- bonds in proteins.

Subunit structure

Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.

Subcellular location: Endoplasmic reticulum lumen. Melanosome. Note: Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

General information above from UniProt

Function for ERP72 (PDIA4) Protein

Genatlas:

  • isomerase activity on S-S bonds in proteins

Homology for human ERP72 (PDIA4)

  • ortholog to murine Cai

Phenotype Information for ERP72 (PDIA4)

Drugs for ERP72 (PDIA4)

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