ERP27

ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartment. PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. Recombinant Human Protein Disulfide Isomerase is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. Recombinant PDI has been found to have moderate effects (25-fold) on the rate of oxidative folding of proteins in vitro. ERP27 is a widely expressed protein which localizes to the ER and may act as a protease, protein disulfide isomerase, thiol-disulfide oxidase or phospholipase. ERP27 doesn't contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

ERP27 Related Areas

Enzyme >>Other>> ERP27

ERP27 Alternative Names

UNQ781/PRO1575, C12orf46, FLJ32115, PDIA8, ER protein 27, endoplasmic reticulum protein 27 kDa, endoplasmic reticulum resident protein 27, protein disulfide isomerase family A, member 8 [Homo sapiens]

1810033M07Rik, 1810047B09Rik, MGC129514, MGC129515, ER protein 27, endoplasmic reticulum resident protein 27, endoplasmic reticulum resident protein ERp27 [Mus musculus]

Summaries for ERP27

Entrez Gene summary for ERP27:

ERP27 is a noncatalytic member of the protein disulfide isomerase (PDI; see MIM 608012) family of endoplasmic reticulum (ER) proteins (Alanen et al., 2006 [PubMed 16940051]).[supplied by OMIM, Mar 2008]

OMIM - description for ERP27:

ERP27 is a noncatalytic member of the protein disulfide isomerase (PDI; see 608012) family of endoplasmic reticulum (ER) proteins (Alanen et al., 2006).

Human ERP27 Protein General Information

 

• Protein names: Endoplasmic reticulum resident protein 27, Short name=ERp27
• Sequence length: 273 AA.
• Sequence similarities: ERP27 belongs to the protein disulfide isomerase family. ERP27 contains 1 thioredoxin domain.
• Subunit structure: ERP27 interacts with PDIA3. ERP27 binds somatostatin-14 via hydrophobic interactions.
• Subcellular location: Endoplasmic reticulum lumen
• Miscellaneous: ERP27 does not contain a CXXC active site motif indicating that it is a catalytically redox-inactive member of the protein disulfide isomerase family.

General information above from UniProt

Function for ERP27 Protein

Genatlas:

• ERP27 is non-catalytic endoplasmic reticulum protein