IRE1 (Protein|Antibody|cDNA Clone|ELISA Kit)

All IRE1 reagents are produced in house and quality controlled, including 4 IRE1 Antibody, 2 IRE1 Lysate, 2 IRE1 Protein. All IRE1 reagents are ready to use.

Recombinant IRE1 proteins are expressed by Baculovirus-Insect Cells with fusion tags as N-GST & His, N-cleavage.

IRE1 antibodies are validated with different applications, which are ELISA, IHC-P, WB.

IRE1 Protein (2)

Species

IRE1 Protein, Human, Recombinant (aa 465-977)

11905-HNCB

Expression host: Baculovirus-Insect Cells

Human IRE1/ERN1 Protein 9879

IRE1 Protein, Human, Recombinant (aa 465-977, His & GST Tag)

11905-H20B

Expression host: Baculovirus-Insect Cells

Human IRE1/ERN1 Protein 9878
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IRE1 Antibody (4)

Application Clonality
Host

Anti-IRE1 Antibody

11905-T48

Specificity: Human

Application: WB,ELISA

Clonality: PAb

Human IRE1/ERN1 Western blot (WB) 6973

Anti-IRE1 Antibody

11905-RP01

Specificity: Human

Application: ELISA

Clonality: PAb

Anti-IRE1 Antibody

11905-MM01

Specificity: Human

Application: ELISA,IHC-P

Clonality: MAb

Human IRE1/ERN1 Immunohistochemistry(IHC) 4216

Anti-IRE1 Antibody

11905-R142

Specificity: Human

Application: ELISA

Clonality: MAb

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IRE1 Lysate (2)

Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases.
Protein
Antibody
Lysate
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