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> ERK2 Protein (MAPK1, MAPK2 Protein) ERK2 Protein (MAPK1, MAPK2 Protein)
Extracellular signal-regulated kinase 2 (Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 1)
ERK2 Protein Products
ERK2 Protein, Recombinant
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| ERK2/MAPK1/MAPK2 | Human | ERK2/MAPK1 Protein, Recombinant, With GST Tag | 10030-H09B |
| ERK2/MAPK1/MAPK2 | Human | MAPK1 / ERK2 Protein, Recombinant, with GST Tag | 50445-M20B |
ERK2 cDNA Clone
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! | Cat. No |
| ERK2/MAPK1/MAPK2 | Human | Homo sapiens ERK2/MAPK1 transcript variant 1 cDNA Clone(NM_002745.4) | HG10030-M |
| ERK2/MAPK1/MAPK2 | Mouse | Mus musculus ERK2/MAPK1 cDNA Clone | MG50445-M |
ERK2 Related Areas
Enzyme>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>ERK2/MAPK1/MAPK2
Signal Transduction>>Protein Kinase>>Intracellular Kinase>>Mitogen-Activated Protein Kinase (MAPK)>>ERK2/MAPK1/MAPK2
ERK2 Alternative Names
ERK2, MAPK1, MAPK2, ERK-2, MAPK 1, MAPK 2, ERK, ERT1, P42MAPK, p42-MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk [Homo sapiens]
Erk2, Mapk1, MAPK2, ERK-2, ERT1, MAPK 1, MAPK 2, ERK, PRKM2, Prkm1, p41mapk, p42mapk, p42-MAPK, 29030612K14Rik, AA407128, AU018647, C78273 [Mus musculus]
ERK2 Related Products
Protein Products
| Molecule | Species | Description //For Detailed Info. and Price------CLICK! |
| JNK1/MAPK8 | Human | JNK1/MAPK8 Protein, Recombinant |
| JNK2/MAPK9 | Human | JNK2/MAPK9 Protein, Recombinant |
| p38 delta/MAPK13 | Human | p38 delta/MAPK13 Protein, Recombinant, with GST Tag |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK14 Protein, Recombinant |
| p38 alpha/MAPK14 | Human | p38 alpha/MAPK148 Protein, Recombinant |
| MAPKAPK3 | Human | MAPKAPK3 Protein, Recombinant |
cDNA Clone Products
ERK2 Background
MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. ERK is a versatile protein kinase that regulates many cellular functions. Growing evidence suggests that extracellular signal-regulated protein kinase 1/2 (ERK1/2) plays a crucial role in promoting cell death in a variety of neuronal systems, including neurodegenerative diseases. It is believed that the magnitude and the duration of ERK1/2 activity determine its cellular function. Activation of ERK1/2 are implicated in the pathophysiology of spinal cord injury (SCI). ERK2 signaling is a novel target associated with the deleterious consequences of spinal injury. ERK-2, also known as Mitogen-activated protein kinase 1 (MAPK1), is a member of the protein kinase superfamily and MAP kinase subfamily. MKP-3 is a dual specificity phosphatase exclusively specific to MAPK1 for its substrate recognition and dephosphorylating activity. The activation of MAPK1 requires its phosphorylation by upstream kinases. Upon activation, MAPK1 translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. MAPK1 is involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. MAPK1 acts as a transcriptional repressor which represses the expression of interferon gamma-induced genes. Transcriptional activity is independent of kinase activity. The nuclear-cytoplasmic distribution of ERK2 is regulated in response to various stimuli and changes in cell context. Furthermore, the nuclear flux of ERK2 occurs by several energy- and carrier-dependent and -independent mechanisms. ERK2 has been shown to translocate into and out of the nucleus by facilitated diffusion through the nuclear pore, interacting directly with proteins within the nuclear pore complex, as well as by karyopherin-mediated transport. ERK2 interacts with the PDE4 catalytic unit by binding to a KIM (kinase interaction motif) docking site located on an exposed beta-hairpin loop and an FQF (Phe-Gln-Phe) specificity site located on an exposed alpha-helix. These flank a site that allows phosphorylation by ERK, the functional outcome of which is orchestrated by the N-terminal UCR1/2 (upstream conserved region 1 and 2) modules.
ERK2 Related Studies
- Houslay MD, et al. (2003) The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Biochem Soc Trans. 31(Pt 6): 1186-90.
- Jivan A, et al. (2010) Reconstitution of the Nuclear Transport of the MAP Kinase ERK2. Methods Mol Biol. 661: 273-85.
- Yu CG, et al. (2010) Involvement of ERK2 in traumatic spinal cord injury. J Neurochem. 113(1): 131-42.
- Subramaniam S, et al. (2010) ERK and cell death: ERK1/2 in neuronal death. FEBS J. 277(1): 22-9.
ERK2 related areas, pathways, and other information
