EPHA1 / EPH receptor A1 Protein

Eph receptor A1

EPHA1 Products

EPHA1 Protein, Recombinant

Molecule	Species	Description	Cat. No
EPHA1	Mouse	EPHA1 / EPH receptor A1 Protein, Recombinant	50827-M08H

EPHA1 cDNA Clone

Molecule	Species	Description	Cat. No
EPHA1	Mouse	EPHA1 cDNA Clone / ORF Clone	MG50827-G

EPHA1 Related Areas

Enzyme>>Protein Kinase>>Receptor Tyrosine Kinase>>EPHA1

Signal Transduction>>Protein Kinase>>Receptor Tyrosine Kinase>> EPHA1

Cancer>>Growth Factor & Receptor>>Receptor Tyrosine Kinase>> EPHA1

EPHA1 Alternative Names

EPH, EPHT, EPHT1, MGC163163[Homo sapiens]

5730453L17Rik, AL033318, Eph, Esk[Mus musculus]

EPHA1 Background

EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.

EPHA1 Related Studies

1. Flanagan JG, et al. (1998) THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT. Annual Review of Neuroscience. 21: 309-45.
2. Wilkinson DG (2000) Eph receptors and ephrins: Regulators of guidance and assembly. International Review of Cytology. 196: 177-244.
3. Zhou R. (1998) The Eph family receptors and ligands. Pharmacol. 77 (3): 151-81.