All EphA1 reagents are produced in house and quality controlled, including 3 EphA1 Antibody, 24 EphA1 Gene, 3 EphA1 Lysate, 3 EphA1 Protein, 2 EphA1 qPCR. All EphA1 reagents are ready to use.
Recombinant EphA1 proteins are expressed by HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
EphA1antibodies are validated with different applications, which are ELISA.
EphA1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each EphA1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
EPHA1 or EPH receptor A1 belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. An important role of Eph receptors and their ligands ephrins is to mediate cell-contact-dependent repulsion. Eph receptors and ephrins also act at boundaries to channel neuronal growth cones along specific pathways, restrict the migration of neural crest cells, and via bidirectional signaling prevent intermingling between hindbrain segments. Eph receptors and ephrins can also trigger an adhesive response of endothelial cells and are required for the remodeling of blood vessels. Eph receptors and ephrins have emerged as key regulators of the repulsion and adhesion of cells that underlie the establishment, maintainence, and remodeling of patterns of cellular organization. The ephrins and Eph receptors are implicated as positional labels that may guide the development of neural topographic maps.