Anti-ENPP7 Antibody

Cat: 10885-MM02

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Anti-ENPP7 Antibody (Mouse Monoclonal antibody) General Information
Product name
Anti-ENPP7 Antibody
Validated applications
Species reactivity
Reacts with: Human
Human ENPP7
Recombinant Human ENPP7 protein ( Catalog#10885-H08H)
This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ENPP7 / NPP-7 (rh ENPP7; Catalog#10885-H08H; NP_848638.2; Met 1-Ser 439). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Monoclonal Mouse IgG1 Clone #5E1F9A6
Protein A
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-ENPP7 Antibody (Mouse Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-ENPP7 Antibody Alternative Names
Anti-ALK-SMase Antibody;Anti-E-NPP7 Antibody;Anti-NPP-7 Antibody;Anti-NPP7 Antibody
ENPP7 Background Information

Ectonucleotide pyrophosphatase / phosphodiesterase family member 7, also known as Alkaline sphingomyelin phosphodiesterase, Intestinal alkaline sphingomyelinase, Alk-Smase, ENPP7 and NPP-7, is a single-pass type I membrane protein which belongs to the nucleotide pyrophosphatase / phosphodiesterase family. ENPP7 / NPP-7 is expressed in the intestines and human bile. ENPP7 / NPP-7 is localized at the surface of the microvillar membrane in small intestine enterocytes, as well as in endosome-like structures and in Golgi complex. The main function of ENPP7 / NPP-7 is to convert the dietary sphingomyelin into ceramide, the sphingolipid messengers via hydrolyzation. ENPP7 / NPP-7 is also reported to exert a phospholipase C activity toward palmitoyl lyso-phosphocholine. The activity of this enzyme is inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Further, It has been shown in studies that decreased levels of ENPP7 / NPP-7 may be associated with human colon cancer.

Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 7
  • Wu J. et al., 2005, Biochem. J. 386:153-60.
  • Wu J. et al., 2004, Carcinogenesis 25:1327-33.
  • Duan R.-D. et al., 2003, J. Lipid Res. 44:1241-50.
  • Duan R.-D. et al., 2003, J. Biol. Chem. 278:38528-36.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-ENPP7 Antibody Rabbit Polyclonal ELISA 10885-RP01
    Anti-ENPP7 Antibody Mouse Monoclonal ICC/IF,IF 10885-MM10
    Anti-ENPP7 Antibody Rabbit Monoclonal ELISA 10885-R001
    Anti-ENPP7 Antibody Rabbit Polyclonal WB,ELISA 10885-RP02
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