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ENPEP / Aminopeptidase A Protein, Antibody, ELISA Kit, cDNA Clone

ENPEP / Aminopeptidase A Related Areas

ENPEP / Aminopeptidase A Related Pathways

ENPEP / Aminopeptidase A Related Product

    ENPEP / Aminopeptidase A Summary & Protein Information

    ENPEP / Aminopeptidase A Background

    Catalytic activity: Release of N-terminal glutamate (and to a lesser extent aspartate) from a peptide.
    Cofactor: Binds 1 zinc ion per subunit (By similarity).
    Subunit structure: Homodimer; disulfide-linked.
    Subcellular location: Membrane; Single-pass type II membrane protein.
    Tissue specificity: Expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. Also found in a variety of other tissues.
    Sequence similarity: Belongs to the peptidase M1 family.C
    General information above from UniProt

    ENPEP, also known as aminopeptidase A, is a member of the peptidase M1 family. Members of this family are involved in response to cadmium ion and proteolysis. They located in 6 components and are expressed in 26 plant structures. ENPEP is expressed by epithelial cells of the proximal tubule cells and the glomerulus of the nephron. It also can be detected in a variety of other tissues. ENPEP probably plays a role in regulating growth and differentiation of early B-lineage cells. It also may play a role in the catabolic pathway of the renin-angiotensin system. ENPEP is a zinc-dependent membrane-bound aminopeptidase that catalyzes the cleavage of glutamatic and aspartatic amino acid residues from the N-terminus of polypeptides. It degrades vasoconstricting angiotensin II into angiotensin III and therefore helps to regulate blood pressure.

    ENPEP / Aminopeptidase A Alternative Name

    ENPEP / Aminopeptidase A Related Studies

  • Speth RC, et al. (2008) The significance of brain aminopeptidases in the regulation of the actions of angiotensin peptides in the brain. Heart Fail Rev. 13(3):299-309.
  • Rose JE, et al. (2010) Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med. 16(7-8):247-53.
  • Pérez I, et al. (2009) Increased APN/CD13 and acid aminopeptidase activities in head and neck squamous cell carcinoma. Head Neck. 31(10):1335-40.
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