ENO1 / Enolase 1 Protein

ENO1 / Enolase 1 Products

ENO1 / Enolase 1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ENO1/Enolase 1	Human	ENO1/Enolase 1 Protein, Recombinant	11554-H07E

ENO1 / Enolase 1 cDNA Clone

Molecule	Species	Description	Cat. No
ENO1/Enolase 1	Human	Human ENO1/Enolase 1 cDNA Clone / ORF Clone	HG11554-M

ENO1 / Enolase 1 Related Areas

Enzyme>>Other>>ENO1/Enolase 1

ENO1 / Enolase 1 Alternative Names

ENO1, ENO1L1, MPB1, NNE, PPH [Homo sapiens]

Eno1, 0610008I15, AL022784, Eno-1, MBP-1, MGC103111, MGC107267 [Mus musculus]

ENO1 / Enolase 1 Background

ENO1 (Enolase 1), also known as alpha-enolase (ENOA), is a key glycolytic enzyme. Aside from its enzymatic function in the glycolytic pathway, alpha-enolase (ENO1) has been implicated in numerous diseases, including metastatic cancer, autoimmune disorders, ischaemia and bacterial infection. ENO1 has tumour suppressor activity and that high level of ENO1 expression has growth inhibitory effects. In tumor cells, ENO1 is upregulated and supports anaerobic proliferation (Warburg effect), it is expressed at the cell surface, where it promotes cancer invasion, and is subjected to a specific array of post-translational modifications, namely acetylation, methylation and phosphorylation. Both ENO1 overexpression and its post-translational modifications could be of diagnostic and prognostic value in cancer. Alpha-enolase, although traditionally considered a glycolytic enzyme, constitutes a receptor for plasminogen on several cell types, serving to localize and promote plasminogen activation pericellularly.

ENO1 / Enolase 1 Related Studies

1. Capello M, et al. (2011) a-Enolase: a promising therapeutic and diagnostic tumor target. FEBS J. 278(7): 1064-74.
2. Tu SH, et al. (2010) Increased expression of enolase alpha in human breast cancer confers tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 121(3): 539-53.
3. Kang HJ, et al. (2008) Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme. Acta Crystallogr D Biol Crystallogr. 64(Pt 6): 651-7.
4. Lopez-Alemany R, et al. (2005) Alpha-enolase plasminogen receptor in myogenesis. Front Biosci. 10: 30-6.
5. Ejeskdr K, et al. (2005) Introduction of in vitro transcribed ENO1 mRNA into neuroblastoma cells induces cell death. BMC Cancer. 5: 161.