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EIF3K Protein, Antibody, ELISA Kit, cDNA Clone

EIF3K Related Areas

EIF3K Related Pathways

EIF3K Related Product

    EIF3K Summary & Protein Information

    EIF3K Background

    Gene Summary: The 700-kD eukaryotic translation initiation factor-3 (eIF3) is the largest eIF and contains at least 12 subunits, including EIF2S12. eIF3 plays an essential role in translation by binding directly to the 40S ribosomal subunit and promoting formation of the 40S preinitiation complex (Mayeur et al., 2003 ).[supplied by OMIM, Mar 2008]
    General information above from NCBI
    Subunit structure: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with CCND3, but not with CCND1 and CCND2.
    Subcellular location: Nucleus. Cytoplasm.
    Tissue specificity: Ubiquitous, with the highest levels of expression in brain, testis and kidney.
    Sequence similarity: Belongs to the eIF-3 subunit K family.C
    General information above from UniProt

    EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. EIF3K is universally expressed in human tissues. It is distributed both in nucleus and cytoplasm. EIF3K is the smallest subunit of eIF3 and it interacts with a number of other subunits of eIF3 and the 40S ribosomal subunit.

    EIF3K Alternative Name

    ARG134,eIF-3 p25,eIF-3 p28,EIF3K,EIF3-p28,EIF3S12,eukaryotic translation initiation factor 3,eukaryotic translation initiation factor 3 subunit 12,eukaryotic translation initiation factor 3 subunit K,HSPC029,M9,MSTP001,muscle specific,muscle-specific gene M9 protein,PLAC24,PLAC-24,PRO1474,PTD001,subunit 12,subunit K, [human]
    1200009C21Rik,eIF-3 p25,Eif3k,Eif3s12,eukaryotic translation initiation factor 3,eukaryotic translation initiation factor 3 subunit 12,eukaryotic translation initiation factor 3 subunit K,subunit 12,subunit K, [mouse]

    EIF3K Related Studies

  • Rual JF. et al., 2005, Nature. 437 (7062): 1173-8.
  • Shen X. et al., 2004, FEBS Lett. 573 (1-3): 139-46.
  • Wei Z. et al., 2004, J Biol Chem. 279 (33): 34983-90.
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