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EGFR/HER1 FITC Rabbit MAb

  • EGFR / HER1 / ErbB1 Antibody (FITC), Rabbit MAb, Flow cytometric analysis
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Human EGFR/ErbB1/HER1 Antibody Product Information
Immunogen:Recombinant Human EGFR Protein (Catalog#10001-H08H)
Clone ID:E01
Ig Type:Rabbit IgG
Concentration:5 μl/Test, 0.1 mg/ml
Formulation:Aqueous solution containing 0.5% BSA and 0.09% sodium azide
Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met 1-Ser 645) and conjugated with FITC under optimum conditions, the unreacted FITC was removed.
Human EGFR/ErbB1/HER1 Antibody FC Application Image
EGFR / HER1 / ErbB1 Antibody (FITC), Rabbit MAb, Flow cytometric analysis
[Click to enlarge image]
Caption:
Profile of anti-EGFR reactivity on A431 cells analyzed by flow cytometry.
Other EGFR/ErbB1/HER1 Antibody Products
EGFR/HER1 Background

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Human EGFR/HER1 References
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
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    Catalog: 10001-RE01-F-100
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    100 Tests
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"