Anti-EGFR Antibody

Cat: 10001-R043
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All EGFR Reagents
Anti-EGFR Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-EGFR Antibody
Validated applications
ELISA,IHC-P,IHC-Fr
Species reactivity
Reacts with: Human
Specificity
Human EGFR
No cross-reactivity in ELISA with Human ErbB2 Human ErbB3
Immunogen
Recombinant Human EGFR / HER1 / ErbB1 protein (Catalog#10001-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human EGFR / HER1 / ErbB1 (rh EGFR / HER1 / ErbB1; Catalog#10001-H08H; NP_005219; Met 1-Ser 645).
Source
Monoclonal Rabbit IgG Clone #043
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-EGFR Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:50-1:200  
IHC-Fr 1:50-1:200  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-EGFR Antibody (Rabbit Monoclonal antibody) Images
Human EGFR/HER1 Immunohistochemistry(IHC) 3062
Immunofluorescence staining of EGFR in monkey skin with rabbit monoclonal antibody (1:50, frozen section). The image showing membrane staining of squamous epithelium cell.
Human EGFR/HER1 Immunohistochemistry(IHC) 4247
Immunochemical staining of human EGFR in human uterine cervix cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to uterine gland.
Human EGFR/HER1 Immunohistochemistry(IHC) 4249
Immunochemical staining of human EGFR in human rectal cancer with rabbit monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). Positive staining was localized to rectal gland. The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Human EGFR/HER1 Immunohistochemistry(IHC) 4251
Immunochemical staining of human EGFR in human placenta with rabbit monoclonal antibody (1:200,formalin-fixed paraffin embedded sections). Positive staining was localized to trophoblast.
Anti-EGFR Antibody Alternative Names
Anti-ERBB Antibody;Anti-ERBB1 Antibody;Anti-HER1 Antibody;Anti-mENA Antibody;Anti-NISBD2 Antibody;Anti-PIG61 Antibody
EGFR Background Information

As a member of the epidermal growth factor receptor (EGFR) family, EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF, amphiregulin, TGF-α, betacellulin, etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation, survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization, the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK, PI3K/PKB and STAT). In addition, EGFR signaling also has been shown to exert action on carcinogenesis and disease progression, and thus EGFR protein is proposed as a target for cancer therapy currently.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
epidermal growth factor receptor
References
  • Schlessinger, J. (2000) Cell signaling by receptor tyrosine kinases. Cell 103(2): 211-25.
  • Giaccone, G. (2005) HER1/EGFR-targeted agents: predicting the future for patients with unpredictable outcomes to therapy. Ann. Oncol. 16(4): 538-48.
  • Yarden, Y., et al. (2001) Untangling the ErbB signalling network. Nat. Rev. Mol. Cell. Biol. 2(2): 127-37.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 90317-T16
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 90317-RP01
    Anti-EGFR Antibody Rabbit Polyclonal WB,ELISA,IP 80100-T52
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 80100-RP01
    Anti-EGFR Antibody Rabbit Polyclonal WB,ELISA,IP 51091-T52
    Anti-EGFR Antibody Rabbit Monoclonal ELISA 51091-R112
    Anti-EGFR Antibody Rabbit Polyclonal WB,ELISA 51091-T48
    Anti-EGFR Antibody Rabbit Monoclonal ELISA 51091-R004
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 51091-RP01
    Anti-EGFR Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det),ICC/IF,IF 10001-R021
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 10001-RP02
    Anti-EGFR Antibody Mouse Monoclonal ELISA 10001-MM01
    Anti-EGFR Antibody (APC) Mouse Monoclonal FCM 10001-MM08-A
    Anti-EGFR Antibody (APC) Rabbit Monoclonal FCM 10001-RE01-A
    Anti-EGFR Antibody Rabbit Polyclonal ELISA,IHC-P 10001-T24
    Anti-EGFR Antibody Rabbit Polyclonal ELISA 10001-RP01
    Anti-EGFR Antibody Rabbit Polyclonal WB 100372-T32
    Anti-EGFR Antibody Rabbit Monoclonal Neutralization 10001-RE10
    Anti-EGFR Antibody (PE) Mouse Monoclonal FCM 10001-MM08-P
    Anti-EGFR Antibody Rabbit Monoclonal ELISA,FCM 10001-RE01
    Anti-EGFR Antibody Mouse Monoclonal FCM,ICC/IF,IF 10001-MM08
    Anti-EGFR Antibody Mouse Monoclonal IHC-P 10001-MM11
    Anti-EGFR Antibody Rabbit Monoclonal ELISA(Cap) 10001-RE11
    Anti-EGFR Antibody (PE) Rabbit Monoclonal FCM 10001-RE01-P
    Anti-EGFR Antibody (FITC) Rabbit Monoclonal FCM 10001-RE01-F
    Anti-EGFR Antibody (FITC) Mouse Monoclonal FCM 10001-MM08-F
    Anti-EGFR Antibody Rabbit Monoclonal Neutralization 10001-REN01
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