EGFL7 (VE-statin)

EGFL7 regulates vascular tubulogenesis in vivo. EGFL7 inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.

EGFL7 (VE-statin) Related Areas

 

EGFL7 (VE-statin) Alternative Names

EGFL7, UNQ187/PRO1449, MGC111117, RP11-251M1.2, VE-STATIN, ZNEU1 [Homo sapiens]

Egfl7, RP23-70A22.2, VE-statin, Zneu1 [Mus musculus]

Summaries for EGFL7 (VE-statin)

Entrez Gene summary for EGFL7:

This EGFL7 gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. EGFL7 protein may play a role in regulating vasculogenesis. EGFL7 protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

Wikipedia summary for EGFL7:

EGF-like domain-containing protein 7 is a protein that in humans is encoded by the EGFL7 gene. Intron 7 of EGFL7 hosts the miR-126 microRNA gene.

Human EGFL7 (VE-statin) Protein General Information

 

• Protein names: Epidermal growth factor-like protein 7, Short name=EGF-like protein 7
• Sequence length: 273 AA.
• Sequence similarities: EGFL7 contains 2 EGF-like domains. EGFL7 contains 1 EMI domain.
• Subcellular location: Secreted

General information above from UniProt

Function for EGFL7 (VE-statin) Protein

UniProtKB:

EGFL7 regulates vascular tubulogenesis in vivo. EGFL7 inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cells adhesion to the substrate in vitro.

Genatlas:

• EGFL7 plays a specific role in regulating vascular tubulogenesis
• EGFL7 is secreted factor implicated in cellular responses such as cell migration and blood vessel formation
• EGFL7 acts as an antagonist of Notch signalling and affecting neural stem cell renewal
• EGFL7 may protect endothelial cell from hyperoxia-induced apoptosis by inhibition of mitochondria-dependent apoptosis pathway
• EGFL7 potentially regulates angiogenesis by an autocrine mechanism involving vasculature alone

Homology for human EGFL7 (VE-statin)

• homolog to murine Egfl7 (78.7pc)