EGF

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EGF Related Areas

Cancer>>Cancer Biomarkers>>EGF

Cancer>>Growth Factor & Receptor>>EGF Family & Receptor>>EGF

EGF Related Pathways

• EGFR Signaling Pathway

EGF Alternative Names

EGF, HOMG4, URG [Homo sapiens]
Egf, AI790464 [Mus musculus]

Summaries for EGF

Entrez Gene summary for EGF :

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.

OMIM - description for EGF :

The EGF gene encodes thrombomodulin, an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin (F2; 176930). Binding of thrombin to this high-affinity receptor alters its specificity toward several substrates, ultimately acting as an antithrombotic factor. The F2:EGF complex activates protein C (PROC; 612283) approximately 1,000 times faster than thrombin alone, and activated protein C degrades clotting factors V (F5; 612309) and VIII (F8; 300841). In addition, EGF can inhibit procoagulant functions of thrombin, such as platelet activation or fibrinogen clotting. EGF can also promote antithrombin III (SERPINC1; 107300) inhibition of thrombin. Thus, thrombomodulin converts thrombin into a physiologic anticoagulant

Wikipedia summary for EGF :

Epidermal growth factor or EGF is a growth factor that stimulates cell growth, proliferation, and differentiation by binding to its receptor EGFR. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds

Human EGF Protein General Information

 

• Protein names: Recommended name: Pro-epidermal growth factor
  Short name: EGF
• Sequence length: 1207 AA
• Domain: EGF-like domain Repeat Signal Transmembrane Transmembrane helix
• Sequence similarities: Contains 9 EGF-like domains. Contains 9 LDL-receptor class B repeats.
• Subunit structure: Interacts with EGFR and promotes EGFR dimerization. Interacts with RHBDF2. Interacts with RHBDF1; may retain EGF in the endoplasmic reticulum and regulates its degradation through the endoplasmic reticulum-associated degradation (ERAD).
• Subcellular location: Membrane; Single-pass type I membrane protein.
• Tissue specificity: Expressed in kidney, salivary gland, cerebrum and prostate.
• Involvement in disease: Defects in EGF are the cause of hypomagnesemia type 4 (HOMG4) [MIM:611718]; also known as renal hypomagnesemia normocalciuric. HOMG4 is a disorder characterized by massive renal hypomagnesemia and normal levels of serum calcium and calcium excretion. Clinical features include seizures, mild-to mederate psychomotor retardation, and brisk tendon reflexes.

General information above from UniProt

Function for EGF Protein

UniProtKB:

Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC By similarity. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate.

Genatlas:

• EGF regulator of cell proliferation
• EGF plays a crucial role in mitogenic regulation of human brain tumor stem cells (Pubmed 18292095)
• differentiation of specific cells and mitogenic factor for cells of ectodermal and mesodermal origin
• antagonistically involved in both PTK2 phosphorylation and dephosphorylation with different mechanisms in a cell (Pubmed 18543351)
• EGF and FGF2, may play an important role in the fate decision of neural crest progenitors and in the development of the peripheral nervous system (Pubmed 19415484)
• activates ERBB1/ERBB1 or ERBB1/ERBB2 dimers
• caspase-8 is necessary for the efficient activation of downstream events associated with epidermal growth factor (EGF) signaling (Pubmed 19470771)
• EGF with nucleotides carry the potential to act synergistically in the control of cell proliferation and cell survival in adult neurogenesis (Pubmed 19549686)
• EGF is involved in nervous system development (Pubmed 20303009)
• EGF-induced cell migration is mediated by the lipase domain of PLCG1 and the subsequent IP(3) generation and intracellular calcium mobilization (Pubmed 20674545)
• EGF promotes breast cancer tumour growth and survival, rapidly induces SERPINE1 expression in the breast adenocarcinoma cell line (Pubmed 20727996)

Phenotype Information for EGF

• Gene/Locus: EFEMP2, FBLN4, UPH1, ARCL1B
• Phenotype: Cutis laxa, autosomal recessive, type IB

Phenotype Information for EGF from OMIM (Online Mendelian Inheritance in Man)

Drugs for EGF

Target	Drug Name	Disease	Drug Status
EGF	Anti-EGFL7	Solid Tumors, non-small cell lung cancer, metastatic colorectal cancer Phase I	Approved

Drugs for EGF from TTD (Therapeutic Targets Database)