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Mouse EGF / Epidermal growth factor Protein (His Tag)

  • Mouse EGF / Epidermal growth factor Protein (His Tag) SDS-PAGE
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Mouse Egf Protein Product Information
Synonym:AI790464
Protein Construction:A DNA sequence encoding the mouse Egf (AAH60741.1) (Met1-Arg1029) was expressed with a polyhistidine tag at the C-terminus.
Species:Mouse
Expressed Host:Human Cells
Shipping:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Mouse Egf Protein QC Testing
Purity:> 90 % as determined by SDS-PAGE.
Endotoxin:<1.0 EU per μg protein as determined by the LAL method.
Stability:Samples are stable for up to twelve months from date of receipt at -70℃
Predicted N Terminal:Trp 29
Molecule Mass:The recombinant mouse Egf consists 1012 amino acids and predicts a molecular mass of 111.3 kDa.
Formulation:Lyophilized from sterile PBS, pH 7.4.
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Mouse Egf Protein Usage Guide
Storage:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
Mouse Egf Protein SDS-PAGE
Mouse EGF / Epidermal growth factor Protein (His Tag) SDS-PAGE
Other Egf Recombinant Protein Products
Description: Active  
Expression host: Human Cells  
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10605-H01H-100
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10605-HNAE-500
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Expression host: Human Cells  
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50482-M01H-100
50482-M01H-1
50482-M01H-500
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Description: Active  
Expression host: Human Cells  
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50482-MNCH-500
50482-MNCH-1
50482-MNCH-100
500 µg 
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Description: Active  
Expression host: Yeast  
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50482-MNAY-500
50482-MNAY-1
50482-MNAY-100
500 µg 
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Expression host: E. coli  
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80446-RNAE-100
80446-RNAE-500
80446-RNAE-1
100 µg 
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Description: Active  
Expression host: E. coli  
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70013-D07E-100
70013-D07E-1
70013-D07E-500
100 µg 
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Epidermal Growth Factor/EGF Background

EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

Mouse Epidermal Growth Factor/EGF References
  • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
  • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
  • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
  • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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    Catalog: 50482-M08H1-50
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    Datasheet & Documentation

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    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"