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Epidermal Growth Factor/EGF Rabbit MAb

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    Human EGF Antibody Product Information
    Immunogen:Recombinant Human EGF protein (Catalog#10605-HNAE)
    Clone ID:008
    Ig Type:Rabbit IgG
    Concentration:
    Formulation:0.2 μm filtered solution in PBS with 5% trehalose
    Preparation:This antibody was obtained from a rabbit immunized with purified, recombinant Human EGF(rh EGF; Catalog#10605-HNAE; NP_001954.2; Asn 971-Arg 1023) .
    Other EGF Antibody Products
    Reactivity: Human  
    Application: B/N  
    • Slide 1
    10605-R001-200
    10605-R001-500
    200 µg 
    500 µg 
    Add to Cart
    Reactivity: Human  
    Application: ELISA  
      10605-RP01-200
      10605-RP01-100
      10605-RP01-400
      200 µg 
      100 µg 
       
      Add to Cart
      Reactivity: Human  
      Application: ELISA  
        10605-T16-100
        10605-T16-50
        10605-T16-200
        100 µg 
        50 µg 
        200 µg 
        Add to Cart
        Reactivity: Mouse  
        Application: ELISA  
          50482-T16-100
          50482-T16-200
          50482-T16-50
          100 µg 
          200 µg 
          50 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  IHC-P  
          • Slide 1
          80446-T24-50
          80446-T24-100
          80446-T24-200
          50 µg 
          100 µg 
          200 µg 
          Add to Cart
          Reactivity: Rat  
          Application: ELISA  
            80446-RP01-100
            80446-RP01-200
            80446-RP01-400
            100 µg 
            200 µg 
             
            Add to Cart
            Reactivity: Canine  
            Application: ELISA  
              70013-MM07-100
              70013-MM07-50
              70013-MM07-200
              100 µg 
              50 µg 
              200 µg 
              Add to Cart
              Reactivity: Canine  
              Application: ELISA  
                70013-RP01-200
                70013-RP01-100
                70013-RP01-400
                200 µg 
                100 µg 
                 
                Add to Cart
                Epidermal Growth Factor/EGF Background

                EGF is the founding member of the EGF-family of proteins. Members of this protein family have highly similar structural and functional characteristics. EGF contains 9 EGF-like domains and 9 LDL-receptor class B repeats. Human EGF is a 6045-Da protein with 53 amino acid residues and three intramolecular disulfide bonds. As a low-molecular-weight polypeptide, EGF was first purified from the mouse submandibular gland, but since then it was found in many human tissues including submandibular gland, parotid gland. It can also be found in human platelets, macrophages, urine, saliva, milk, and plasma. EGF is a growth factor that stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. It results in cellular proliferation, differentiation, and survival. Salivary EGF, which seems also regulated by dietary inorganic iodine, also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. EGF acts by binding with high affinity to epidermal growth factor receptor on the cell surface and stimulating the intrinsic protein-tyrosine kinase activity of the receptor. The tyrosine kinase activity, in turn, initiates a signal transduction cascade that results in a variety of biochemical changes within the cell - a rise in intracellular calcium levels, increased glycolysis and protein synthesis, and increases in the expression of certain genes including the gene for EGFR - that ultimately lead to DNA synthesis and cell proliferation.

                Human Epidermal Growth Factor/EGF References
              • Chen JX, et al. (2011) Involvement of c-Src/STAT3 signal in EGF-induced proliferation of rat spermatogonial stem cells. Mol Cell Biochem. 358(1-2):67-73.
              • Guo Y, et al. (2012) Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer. Oncol Rep. 27(1):286-92.
              • Kim S, et al. (2012) Smad7 acts as a negative regulator of the epidermal growth factor (EGF) signaling pathway in breast cancer cells. Cancer Lett. 314(2):147-54.
              • Chatterton RT Jr, et al. (2010) Breast ductal lavage for assessment of breast cancer biomarkers. Horm Cancer. 1(4):197-204.
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                Catalog: 10605-R008-50
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                Datasheet & Documentation

                All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
                Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"