EED / Embryonic Ectoderm Development Protein

EED / Embryonic Ectoderm Development Products

EED / Embryonic Ectoderm Development Protein, Recombinant

Molecule	Species	Description	Cat. No
EED/Embryonic Ectoderm Development	Human	EED/Embryonic Ectoderm Development Protein, Recombinant, with GST Tag	11307-H20B

EED / Embryonic Ectoderm Development cDNA Clone

Molecule	Species	Description	Cat. No
EED/Embryonic Ectoderm Development	Human	Human EED/Embryonic Ectoderm Development cDNA Clone / ORF Clone	HG11307-M

EED / Embryonic Ectoderm Development Related Areas

Signal Transduction>>Transcription Factor & Regulator>>EED/Embryonic Ectoderm Development

EED / Embryonic Ectoderm Development Alternative Names

EED, Embryonic Ectoderm Development, HEED, WAIT1 [Homo sapiens]

Eed, Embryonic Ectoderm Development, ENSMUSG00000039373, l(7)5Rn, l7Rn5, lusk [Mus musculus]

EED / Embryonic Ectoderm Development Background

Polycomb protein Embryonic Ectoderm Development (EED) is a member of the Polycomb-group (PcG) family. The EED protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. EED is an established transcriptional repressor, as a novel NIPP1 interactor. NIPP1 only interacted with full-length EED, whereas two EED interaction domains were mapped to the central and COOH-terminal thirds of NIPP1. In mammalian cells, EED is present as four distinct isoforms, which are believed to be produced by utilizing four distinct, in-frame translation start sites in a common EED mRNA. The extra sex combs (esc) gene of Drosophila and its mammalian homologue embryonic ectoderm development (EED) play pivotal roles in establishing Polycomb-group (Pc-G) mediated transcriptional silencing of regulatory genes during early development. EED/Sox2 regulatory loop contributes to the maintenance of self-renewal in embryonic stem (ES) cells by controlling histone methylation and acetylation. EED has been defined by the inability of embryos homozygous for certain c deletions to develop beyond the early stages of gastrulation.

EED / Embryonic Ectoderm Development Related Studies

1. Ura H, et al. (2011) Eed/Sox2 regulatory loop controls ES cell self-renewal through histone methylation and acetylation. EMBO J. 30(11): 2190-204.
2. Montgomery ND, et al. (2007) Molecular and functional mapping of EED motifs required for PRC2-dependent histone methylation. J Mol Biol. 374(5): 1145-57.
3. Jin Q, et al. (2003) The protein phosphatase-1 (PP1) regulator, nuclear inhibitor of PP1 (NIPP1), interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor. J Biol Chem. 278(33): 30677-85.
4. Showell C, et al. (2002) Identification of putative interaction partners for the Xenopus Polycomb-group protein Xeed. Gene. 291(1-2): 95-104.
5. Rinchik EM, et al. (1993) N-ethyl-N-nitrosourea-induced prenatally lethal mutations define at least two complementation groups within the embryonic ectoderm development (eed) locus in mouse chromosome 7. Mamm Genome. 4(7): 349-53.