EDAR Protein, Cynomolgus, Recombinant (Fc Tag)

Cat: 90111-C02H
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EDAR Protein, Cynomolgus, Recombinant (Fc Tag) Product Information
Purity
> 95 % as determined by SDS-PAGE
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Activity
Testing in progress
Protein Construction
A DNA sequence encoding the cynomolgus EDAR (Met1-Ala187) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
Expressed Host
HEK293 Cells
Species
Cynomolgus
Predicted N Terminal
Glu 27
Molecule Mass
The recombinant cynomolgus EDAR is a disulfide-linked homodimer. The reduced monomer comprises 404 amino acids and has a calculated molecular mass of 44.6 KDa.The apparent molecular mass of the protein is approximately 60-64 KDa respectively in SDS-PAGE.
Formulation
Lyophilized from sterile PBS, pH 7.4
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
Stability & Storage
Samples are stable for up to twelve months from date of receipt at -70℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution
A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
EDAR Protein, Cynomolgus, Recombinant (Fc Tag) in SDS-PAGE
Cynomolgus EDAR/Ectodysplasin A Receptor Protein 12812
EDAR Background Information

Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.

Full Name
ectodysplasin A receptor
References
  • Elomaa O, et al. (2001) Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. Hum Mol Genet. 10 (9): 953-62.
  • Koppinen P, et al. (2001) Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res. 269 (2): 180-92.
  • Chassaing N, et al. (2006) Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia. Hu. Mutat. 27 (3): 255-9.
  • Other EDAR Proteins

    Cynomolgus EDAR Proteins

    Product Name Cat.No.
    EDAR Protein, Cynomolgus, Recombinant (His Tag) 90111-C08H

    Rat EDAR Proteins

    Product Name Cat.No.
    EDAR Protein, Rat, Recombinant (Fc Tag) 80228-R02H

    Human EDAR Proteins

    Product Name Cat.No.
    EDAR Protein, Human, Recombinant (His Tag) 11577-H08H
    EDAR Protein, Human, Recombinant (Fc Tag) 11577-H02H
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