Ectodysplasin A Receptor
EDAR Protein, Recombinant
EDAR cDNA Clone
EDAR Related Areas
Immunology>>Cytokine & Receptor>>TNF Superfamily>>EDAR
EDAR Alternative Names
EDAR, DL, ED1R, ED3, ED5, EDA-A1R, EDA1R, EDA3, FLJ94390, HRM1 [Homo sapiens]
Edar, ED1R, ED3, ED5, EDA-A1R, EDA3, dl [Mus musculus]
Tumor necrosis factor receptor superfamily member EDAR is a Single-pass type I membrane protein. Edar was expressed reiteratively in signaling centers regulating key steps in morphogenesis. activin signaling from mesenchyme induces the expression of the TNF receptor edar in the epithelial signaling centers, thus making them responsive to Wnt-induced ectodysplasin from the nearby ectoderm. This is the first demonstration of integration of the Wnt, activin, and TNF signaling pathways. Defects in EDAR are a cause of ectodermal dysplasia anhidrotic (EDA), also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
EDAR Related Studies
- Elomaa O, et al. (2001) Ectodysplasin is released by proteolytic shedding and binds to the EDAR protein. Hum Mol Genet. 10 (9): 953-62.
- Koppinen P, et al. (2001) Signaling and subcellular localization of the TNF receptor Edar. Exp Cell Res. 269 (2): 180-92.
- Chassaing N, et al. (2006) Mutations in EDAR account for one-quarter of non-ED1-related hypohidrotic ectodermal dysplasia. Hu. Mutat. 27 (3): 255-9.
TNF Superfamily Ligands
TNF Receptor Superfamily