- EGFR Signaling Pathway
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- p53 Pathway
- NF-kB Pathway
- Cytokine Signaling
|Catalog||Size (Price)||Quantity||In Stock||Operation|
Ectodysplasin A2 receptor Protein Datasheet
EDA2R / TNFRSF27 Protein Price Inquiry ( Available Sizes )
EDA2R / TNFRSF27 Protein Product Information
|Synonym :||EDA2R,Tnfrsf27, Xedar|
A DNA sequence encoding the mouse EDA2R (Q8BX35)(Met1-Thr138) was expressed, fused with the Fc region of human IgG1 at the C-terminus.
|Expression Host:||Human Cells|
EDA2R / TNFRSF27 Protein QC Testing
|Purity:||> 95% as determined by SDS-PAGE||SDS-PAGE:
EDA2R / TNFRSF27 protein
|Endotoxin:||< 1.0 EU per μg of the protein as determined by the LAL method|
|Stability:||Samples are stable for up to twelve months from date of receipt at -70℃|
|Predicted N terminal:||Met|
The recombinant mouse EDA2R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 379 amino acids and has a predicted molecular mass of 42.4 kDa. The apparent molecular mass of the protein is approximately 49 kDa in SDS-PAGE under reducing conditions due to glycosylation.
|Formulation:||Lyophilized from sterile PBS, pH7.4.
EDA2R / TNFRSF27 Protein Usage Guide
|Storage:||Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.|
|Reconstitution:||A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.|
EDA2R / TNFRSF27 Protein Related Products & Topics
|Molecule||Species||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|XEDAR/EDA2R||Human||EDA2R/XEDAR/TNFRSF27 Protein, Recombinant||11845-H08H|
|XEDAR/EDA2R||Mouse||EDA2R / TNFRSF27 Protein, Recombinant||50411-M02H|
|EDA2R||Rat||EDA2R / TNFRSF27 Protein, Recombinant||80206-R02H|
|EDA2R||Rat||EDA2R / TNFRSF27 Protein, Recombinant||80206-R08H|
|Molecule||Application||Description //For Detailed Info. and Price------CLICK!||Cat. No|
|WB,ELISA||Mouse Monoclonal Antibody||11845-MM05|
|WB,ELISA||Rabbit Polyclonal Antibody (Antigen Affinity Purified)||11845-RP02|
EDA2R / TNFRSF27 Protein Description
Tumor necrosis factor receptor superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2 receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type I II membrane protein. TNFRSF27 / EDA2R contains three TNFR-Cys repeats. It is a new member of the tumor necrosis factor receptor family that has been shown to be highly expressed in ectodermal derivatives during embryonic development and binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 / EDA2R is a receptor for EDA isoform A2, but not for EDA isoform A1. TNFRSF27 / EDA2R mediates the activation of the NF-kappa-B and JNK pathways. The activation seems to be mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA gene. Mutations in EDA give rise to a clinical syndrome characterized by loss of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of ectodysplasin that differ only by an insertion of two amino acids. This insertion functions to determine receptor binding specificity, such that EDA-A1 binds only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct, X-linked ectodysplasin-A2 receptor (XEDAR).
- Yan M. et al., 2000,Science. 290: 523-7.
- Sinha SK. et al., 2002, J Biol Chem. 277: 44953-61.
- Prodi DA. et al., 2008, J Invest Dermatol. 128 (9): 2268-70.
|Tumor Necrosis Factor (TNF) Family & Receptor|