ECM1 Protein & Antibody

Extracellular matrix protein 1

ECM1 Protein & Antibody

ECM1 Protein, Recombinant

Molecule	Species	Description	Cat. No
ECM1	Human	ECM1 Protein, Recombinant	10362-H08H
ECM1	Mouse	ECM1 Protein, Recombinant	50331-M08H

  10362-H08H:  Measured by its ability to bind human MMP-9 in a functional ELISA.

  50331-M08H:  Measured by its ability to bind human MMP-9 in a functional ELISA.

ECM1 All Protein and Antibody

ECM1 Antibody

Molecule	Application	Description	Cat. No
Human ECM1	WB, ELISA	Mouse Monoclonal Antibody	10362-MM03
Human ECM1	WB, ELISA	Rabbit Monoclonal Antibody	10362-R015
Human ECM1	ELISA	Rabbit Polyclonal Antibody	10362-RP01
Human ECM1	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10362-RP02
Mouse ECM1	WB, ELISA	ECM1 Antibody	50331-RP01
Mouse ECM1	WB, ELISA	ECM1 Antibody (Antigen Affinity Purified)	50331-RP02

TECM1 ELISA Kit

Molecule	Application	Description	Cat. No
Human ECM1	ELISA	ECM1 ELISA Kit	SEK10362

TECM1 cDNA Clone

Molecule	Species	Description	Cat. No
ECM1	Human	Homo sapiens ECM1 transcript variant 1 cDNA Clone(NM_004425.2)	HG10362-M
ECM1	Mouse	Mus musculus ECM1 cDNA Clone	MG50331-M

ECM1 Related Areas

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>ECM1

Cancer>>Cancer Biomarkers>>ECM1

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Extracellular Matrix Protein>>ECM1

ECM1 Alternative Names

ECM1, RP11-54A4.6 [Homo sapiens]

Ecm1, AI663821, p85 [Mus musculus]

ECM1 Background

Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (540 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling. 

ECM1 Related Studies

1. Oyama N, et al. (2003) Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet. 362(9378): 118-23.
2. Chan I, et al. (2004) Rapid diagnosis of lipoid proteinosis using an anti-extracellular matrix protein 1 (ECM1) antibody. J Dermatol Sci. 35(2): 151-3.
3. Lupo I, et al. (2005) A novel mutation of the extracellular matrix protein 1 gene (ECM1) in a patient with lipoid proteinosis (Urbach-Wiethe disease) from Sicily. Br J Dermatol. 153(5): 1019-22.
4. Sander CS, et al. (2006) Expression of extracellular matrix protein 1 (ECM1) in human skin is decreased by age and increased upon ultraviolet exposure. Br J Dermatol. 154(2): 218-24.