ECM1 Matched ELISA Antibody Pair Set,Human

Cat: SEK10362

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ECM1 Matched ELISA Antibody Pair Set,Human General Information

Product name
ECM1 Matched ELISA Antibody Pair Set,Human
Assay type
Solid Phase Sandwich ELISA
Specificity
Quantitative determination of Human ECM1
Assay range
39.06-2500
Materials provided
1. Capture Antibody 1 mg/mL of mouse anti-Human ECM1 monoclonal antibody (in PBS, pH 7.4). Dilute to a working concentration of 2 μg/mL in PBS before coating. (Catalog: # 10362-MM01)
2. Detection Antibody 0.2 mg/mL of rabbit anti-Human ECM1 monoclonal antibody conjugated to horseradish-peroxidase (HRP) (in PBS, 50 % HRP-Protector, pH 7.4, store at 4℃). Dilute to working concentration of 0.8 μg/mL in detection antibody dilution buffer before use. (Catalog: # 10362-R030)
3. Standard Each vial contains 50 ng of recombinant Human ECM1. Reconstitute with 1 mL detection antibody dilution buffer. After reconstitution, store at -20℃ to -80℃ in a manual defrost freezer. A seven-point standard curve using 2-fold serial dilutions in sample dilution buffer, and a high standard of 2500 pg/mL is recommended.
Product overview
This ECM1 Matched ELISA Antibody Pair Set,Human is a solid phase sandwich ELISA for quantitative determination of Human ECM1 . It contains Human ECM1 capture antibody, Human ECM1 detector antibody (HRP) and a highly purified HEK293-expressed recombinant Human ECM1 protein. This Pair Set is at affordable price for researchers.
Shipping
This Matched ELISA Antibody Pair Set is shipped at ambient temperature.
Storage
Capture Antibody: Aliquot and store at -20℃ to -80℃ for up to 6 months from date of receipt. Avoid repeated freeze-thaw cycles.
Detection Antibody: Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!
Standard: Store lyophilized standard at -20℃ to -80℃ for up to 6 months from date of receipt. Aliquot and store the reconstituted Standard at -80℃ for up to 1 month. Avoid repeated freeze-thaw cycles.

ECM1 Matched ELISA Antibody Pair Set,Human Images

Human ECM1  ELISA Pair Set Standard Curve 13827

ECM1 Matched ELISA Antibody Pair Set,Human Alternative Names

URBWD Matched ELISA Antibody Pair Set, Human

ECM1 Background Information

Extracellular matrix protein 1 (ECM1) is a secreted glycoprotein and playing a pivotal role in endochondral bone formation, angiogenesis, and tumour biology. Three splice variants have been identified: ECM1a (54 aa) is most widely expressed, with highest expression in the placenta and heart; ECM1b (415 aa) is differentiation-dependent expressed and found only in tonsil and associated with suprabasal keratinocytes; ECM1c (559 aa) accounts for approximately 15% of skin ECM1. Although ECM1 is not tumor specific, is significantly elevated in many malignant epithelial tumors and is suggested as a possible trigger for angiogenesis, tumor progression and malignancies. It also has been shown to regulate endochondral bone formation, skeletal development and tissue remodeling. 
Full Name
extracellular matrix protein 1
Research Areas
References
  • Oyama N, et al. (2003) Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet. 362(9378): 118-23.
  • Chan I, et al. (2004) Rapid diagnosis of lipoid proteinosis using an anti-extracellular matrix protein 1 (ECM1) antibody. J Dermatol Sci. 35(2): 151-3.
  • Lupo I, et al. (2005) A novel mutation of the extracellular matrix protein 1 gene (ECM1) in a patient with lipoid proteinosis (Urbach-Wiethe disease) from Sicily. Br J Dermatol. 153(5): 1019-22.
  • Sander CS, et al. (2006) Expression of extracellular matrix protein 1 (ECM1) in human skin is decreased by age and increased upon ultraviolet exposure. Br J Dermatol. 154(2): 218-24.
  • Product Description Assay Range (pg/ml) Sample Type Catalog# (PDF)
    ECM1 ELISA Kit, Human Serum KIT10362

    Differential diagnosis of azoospermia with proteomic biomarkers ECM1 and TEX101 quantified in seminal plasma

    Author:
    Drabovich, AP;Dimitromanolakis, A;Saraon, P;Soosaipillai, A;Batruch, I;Mullen, B;Jarvi, K;Diamandis, EP;
    Year:
    2013
    Journal:
    Sci Transl Med
    Application:
    ELISA

    PubMed ID: 24259048

     
    info info
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