ECHS1 cDNA ORF Clone in Cloning Vector, Human

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ECHS1 cDNA ORF Clone in Cloning Vector, Human: General Information

Gene
Species
Human
NCBI Ref Seq
RefSeq ORF Size
873 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
Description
Full length Clone DNA of Human enoyl CoA hydratase, short chain, 1, mitochondrial.
Plasmid
Vector
Sequencing Primers
SP6 and T7 or M13-47 and RV-M
Quality Control
The plasmid is confirmed by full-length sequencing.
Screening
Antibiotic in E.coli
Ampicillin
Storage & Shipping
Shipping
Each tube contains lyophilized plasmid.
Storage
The lyophilized plasmid can be stored at ambient temperature for three months.

ECHS1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

ECHS1 cDNA ORF Clone in Cloning Vector, Human: Alternative Names

ECHS1D cDNA ORF Clone, Human; SCEH cDNA ORF Clone, Human

ECHS1 Background Information

Overexpression of ECHS1 occurs in different cancers, including hepatocellular carcinoma (HCC). The coexistence of HBs and ECHS1 enhances HepG2 cell apoptosis, affects ECHS1 localization in the mitochondria and induces apoptosis by decreasing the mitochondrial membrane potential (MMP). These findings suggest that ECHS1 may be applied as a potential therapeutic target during the treatment of HBV-related hepatitis or HCC. The human ECHS1 gene encodes the short-chain enoyl coenzyme A hydratase, the enzyme that catalyzes the second step of beta-oxidation of fatty acids in the mitochondrial matrix. ECHS1 protein expression was severely depleted in the patient's skeletal muscle and patient-derived myoblasts. Short-chain enoyl-CoA hydratase (ECHS1) is a multifunctional mitochondrial matrix enzyme that is involved in the oxidation of fatty acids and essential amino acids such as valine. Silencing ECHS1 to attenuate proliferation and induce autophagy may make it a novel cancer therapy target.
Full Name
enoyl CoA hydratase, short chain, 1, mitochondrial
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