EBP1 / PA2G4 Protein

proliferation-associated 2G4, 38kDa

EBP1 / PA2G4 Products

EBP1 / PA2G4 Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat No
EBP1 / PA2G4	Human	EBP1 / PA2G4 Protein, Recombinant	12994-H07E

EBP1 / PA2G4 Related Areas

Signal Transduction>>Transcription Factor & Regulator>>EBP1 / PA2G4

EBP1 / PA2G4 Alternative Names

EBP1, HG4-1, p38-2G4, ErbB-3 binding protein 1, ErbB3-binding protein Ebp1, cell cycle protein p38-2G4 homolog, erbB3-binding protein 1, proliferation-associated protein 2G4 [Homo sapiens]

38kDa, AA672939, Ebp1, Plfap, ErbB3-binding protein 1, IRES-specific cellular trans-acting factor 45 kDa, ITAF45, mpp1, proliferation-associated 2G4, 38kD, proliferation-associated protein 1, proliferation-associated protein 2G4, protein p38-2G4 [Mus musculus]

EBP1 / PA2G4 Background

EBP1, also known as PA2G4, is an RNA-binding protein which belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines. EBP1 also present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein is a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. PA2G4 can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. EBP1 has been implicated in growth inhibition and the induction of differentiation of human cancer cells. It seems to be involved in growth regulation. EBP1 also mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site).

EBP1 / PA2G4 Related Studies

1. Yoo J Y, et al. (2000) Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. Br J Cancer. 82(3):683-90.
2. Andersen JS, et al. (2002) Directed proteomic analysis of the human nucleolus. Curr Biol. 12(1):1-11.
3. Lehner B, et al. (2004) A protein interaction framework for human mRNA degradation. Genome Res. 14 (7):1315-23.