E-Selectin Protein & Antibody (CD62E, ELAM-1)

Cluster of Differentiation 62E, Endothelial Leukocyte Adhesion Molecule-1

E-Selectin Products

E-Selectin Protein, Recombinant

Molecule	Species	Description	Cat. No
E-Selectin/CD62E	Human	E-Selectin/CD62E/Fc Protein, Recombinant	10335-H03H
E-Selectin/CD62E	Human	E-Selectin/CD62E Protein, Recombinant	10335-H08H
E-Selectin/CD62E	Rat	E-Selectin/CD62E Protein, Recombinant	80033-R08H

  10335-H03H:  When cells are added to E-selectin coated plates (2µg/mL, 100 µL/well) approximately 90 %-100 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.

  10335-H08H:  When cells are added to E-selectin coated plates (2µg/mL, 100 µL/well) approximately 85 %-95 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of U937 human histiocytic lymphoma cells.

E-Selectin Antibody

Molecule	Application	Description	Cat. No
Human E-Selectin/CD62E	ELISA	Mouse Monoclonal Antibody	10335-MM03
Human E-Selectin/CD62E	WB, ELISA	Rabbit Monoclonal Antibody	10335-R040
Human E-Selectin/CD62E	WB, ELISA	E-Selectin / CD62e Antibody	10335-R103
Human E-Selectin/CD62E	WB, ELISA	Rabbit Polyclonal Antibody	10335-RP01
Human E-Selectin/CD62E	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	10335-RP02
Rat E-Selectin/CD62E	WB, ELISA	Rabbit Polyclonal Antibody (Antigen Affinity Purified)	80033-RP02

E-Selectin ELISA Kit

Molecule	Application	Description	Cat. No
Human E-Selectin/CD62E	ELISA	E-Selectin/CD62E ELISA Kit	SEK10335

E-Selectin cDNA Clone

Molecule	Species	Description	Cat. No
E-Selectin/CD62E	Human	Homo sapiens E-Selectin/CD62E cDNA Clone(NM_000450.2)	HG10335-M
E-Selectin/CD62E	Mouse	Mouse E-Selectin/CD62E cDNA Clone / ORF Clone	MG50736-G
E-Selectin/CD62E	Rat	Rattus norvegicus E-Selectin/CD62E cDNA Clone	RG80033-M

E-Selectin Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Selectin/CD62E

Cardiovascular>>Platelet>>E-Selectin/CD62E

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Endothelial Cell Marker>>E-Selectin/CD62E

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Selectin/CD62E

Immunology>>Adaptive Immunity>>T Cell>>T Cell Migration/Adhesion>>E-Selectin/CD62E

Immunology>>Adhesion Molecule>>Lectin>>E-Selectin/CD62E

Immunology>>Cluster of Differentiation>>T Cell CD Antigen>>T Cell Migration/Adhesion>>E-Selectin/CD62E

E-Selectin Alternative Names

E-Selectin, CD62e, ELAM-1, ELAM1, ELAM, SELE, RP1-117P20.2, ESEL, LECAM2

E-Selectin Background

E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.

E-Selectin Related Studies

1. Roldán V, et al. (2003) Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature. Thromb Haemost. 90(6): 1007-20.
2. Kawase J, et al. (2009) Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine. Oncol Rep. 22(6): 1293-7.
3. Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.
4. Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80.