Anti-E-Selectin Antibody

Cat: 10335-RP02
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Anti-E-Selectin Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-E-Selectin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human E-Selectin
Immunogen
Recombinant Human E-selectin / CD62E protein (Catalog#10335-H08H)
Preparation
Produced in rabbits immunized with purified, recombinant Human CD62E / E-selectin (rh CD62E; Catalog#10335-H08H; NP_000441.2; Met 1-Pro 556). CD62E specific IgG was purified by human CD62E affinity chromatography .
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-E-Selectin Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-E-Selectin Antibody Alternative Names
Anti-CD62E Antibody;Anti-ELAM Antibody;Anti-ELAM1 Antibody;Anti-ESEL Antibody;Anti-LECAM2 Antibody
E-Selectin Background Information

E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes involved in cancer cell metastasis. E-selectin exhibits a complex mosaic structure consisting of a large extracellular region comprised of a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain, followed by a transmembrane region and a relatively short (32 aa) cytoplasmic tail. As a member of the LEC-CAM or selectin family, E-selectin recognises and binds to sialylated carbohydrates including members of the Lewis X and Lewis A families found on monocytes, granulocytes, and T-lymphocytes. E-selectin supports rolling and stable arrest of leukocytes on activated vascular endothelium, and furthermore, it was indicated that it can also transduce an activating stimulus via the MAPK cascade into the endothelial cell during leukocyte adhesion. E-selectin regulates adhesive interactions between certain blood cells and endothelium. The soluble form of E selectin (sE-selectin) is a marker of endothelial activation, and has a potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial. soluble E-selectin is inversely associated with the muscular component of the left ventricle, thereby suggesting that the lack of such a reparative factor may be associated with cardiac remodeling in end-stage renal disease (ESRD) patients. In addition, this adhesion molecule appears to be involved in the pathogenesis of atherosclerosis.

Full Name
selectin E
References
  • Roldn V, et al. (2003) Soluble E-selectin in cardiovascular disease and its risk factors. A review of the literature. Thromb Haemost. 90(6): 1007-20.
  • Kawase J, et al. (2009) Increase in E-selectin expression in umbilical vein endothelial cells by anticancer drugs and inhibition by cimetidine. Oncol Rep. 22(6): 1293-7.
  • Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4.
  • Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80.
  • Product Description Host Clonality Application Catalog# (PDF)
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    Anti-E-Selectin Antibody Rabbit Monoclonal ELISA,ELISA(Det) 80033-R046
    Anti-E-Selectin Antibody Rabbit Monoclonal ELISA(Cap) 80033-R102
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    Anti-E-Selectin Antibody Rabbit Polyclonal ELISA 50736-T16
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    Anti-E-Selectin Antibody Rabbit Monoclonal WB 50736-R015
    Anti-E-Selectin Antibody Rabbit Monoclonal ICC/IF,IF 10335-R208
    Anti-E-Selectin Antibody (PE) Rabbit Monoclonal FCM 10335-R103-P
    Anti-E-Selectin Antibody (APC) Rabbit Monoclonal FCM 10335-R103-A
    Anti-E-Selectin Antibody (PE) Mouse Monoclonal FCM 10335-MM10-P
    Anti-E-Selectin Antibody Mouse Monoclonal ELISA(Cap) 10335-MM04
    Anti-E-Selectin Antibody (APC) Mouse Monoclonal FCM 10335-MM10-A
    Anti-E-Selectin Antibody Rabbit Polyclonal ELISA 10335-T16
    Anti-E-Selectin Antibody Rabbit Polyclonal ELISA 10335-RP01
    Anti-E-Selectin Antibody Mouse Monoclonal FCM 10335-MM10
    Anti-E-Selectin Antibody Mouse Monoclonal ELISA 10335-MM03
    Anti-E-Selectin Antibody (FITC) Mouse Monoclonal FCM 10335-MM10-F
    Anti-E-Selectin Antibody Rabbit Monoclonal WB,ELISA,ELISA(Det) 10335-R040
    Anti-E-Selectin Antibody (FITC) Rabbit Monoclonal FCM 10335-R103-F
    Anti-E-Selectin Antibody Rabbit Monoclonal ELISA,FCM 10335-R103
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