E-Cadherin Protein & Antibody (CDH1, CD324)

Epithelial-Cadherin (Cadherin 1/Cluster of Differentiation 324)

E-Cadherin Products

E-Cadherin Protein, Recombinant

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
E-Cadherin/CDH1/CD324	Human	E-Cadherin / CDH1 / /CD324 Protein, Recombinant	10204-H08H
E-Cadherin/CDH1/CD324	Mouse	E-Cadherin / CDH1 / CD324 Protein, Recombinant	50671-M08H
E-Cadherin/CDH1/CD324	Rat	E-cadherin / CDH1 / Cadherin-1 Protein, Recombinant	80274-R02H

  10204-H08H:  When cells are added to E-Cad coated plates (1.5 µg/mL, 100 µL/well) , approximately 60 %-80 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells.

E-Cadherin Antibody

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human E-Cadherin/CDH1/CD324	WB, ELISA, ICC/IF, IF	Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody	10204-MM04
Human E-Cadherin/CDH1/CD324	WB, ELISA	Cadherin-1 / CDH1 / CD324 / E-Cadherin Mouse MAb	10204-MM07
Human E-Cadherin/CDH1/CD324	FCM	Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody ( FITC )	10204-MM08-F
Human E-Cadherin/CDH1/CD324	FCM	Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody ( PE )	10204-MM08-P
Human E-Cadherin/CDH1/CD324	ELISA	Cadherin-1 / CDH1 / CD324 / E-Cadherin Mouse MAb	10204-MM12
Human E-Cadherin/CDH1/CD324	WB, ELISA	E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb	10204-RP01
Human E-Cadherin/CDH1/CD324	WB, ELISA	E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb (Antigen Affinity Purified)	10204-RP02
Mouse E-Cadherin/CDH1/CD324	WB, ELISA	E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb (Antigen Affinity Purified)	50671-RP02

E-Cadherin ELISA Kit

Molecule	Application	Description //For Detailed Info. and Price------CLICK!	Cat. No
Human E-Cadherin/CDH1/CD324	ELISA	E-Cadherin / CDH1 / CD324 ELISA Kit	SEK10204

E-Cadherin cDNA Clone

Molecule	Species	Description //For Detailed Info. and Price------CLICK!	Cat. No
E-Cadherin/CDH1/CD324	Human	E-Cadherin / CDH1 / CD324 cDNA Clone / ORF Clone	HG10204-G
E-Cadherin/CDH1/CD324	Human	Human E-Cadherin ORF Expression Clone, FLAG-tagged	HG10204-G-F
E-Cadherin/CDH1/CD324	Rat	E-Cadherin / CDH1 / CD324 cDNA Clone / ORF Clone	RG80274-G

E-Cadherin Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>E-Cadherin/CDH1/CD324

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Stem Cell (CSC)>>E-Cadherin/CDH1/CD324

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Biomarkers>>E-Cadherin/CDH1/CD324

Immunology>>Adhesion Molecule>> Cadherin>>E-Cadherin/CDH1/CD324

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>E-Cadherin/CDH1/CD324

Immunology>>Cluster of Differentiation>>Other>>E-Cadherin/CDH1/CD324

E-Cadherin Alternative Names

E-Cadherin, CDH1, CD324, Arc-1, CDHE, ECAD, LCAM, UVO [Homo sapiens]

E-Cadherin, Cdh1, Ecad, L-CAM, AA960649, MGC107495, UVO, Um [Mus musculus]

E-Cadherin Related Products

Protein Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
N-Cadherin/CD325/CDH2	Human	N-Cadherin/CD325/CDH2 Protein, Recombinant
R-Cadherin/CDH4	Human	R-Cadherin/CDH4 Protein, Recombinant
VE-Cadherin/CD144/CDH5	Human	VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5	Mouse	VE-Cadherin/CD144/CDH5 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6	Human	Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8	Human	Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12	Human	Cadherin-12/CDH12 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16	Human	KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
Cadherin-17/LI-cadherin	Human	Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule	Applications	Description //For Detailed Info. and Price------CLICK!
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb
Human R-Cadherin/CDH4	WB, ELISA	R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse VE-Cadherin/CD144/CDH5	WB, ELISA	Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule	Species	Description //For Detailed Info. and Price------CLICK!
N-Cadherin/CD325/CDH2	Human	Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3	Human	Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
VE-Cadherin/CD144/CDH5	Human	Homo sapiens VE-Cadherin/CD144/CDH5 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5	Mouse	Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone
Cadherin-6/K-Cadherin/CDH6	Human	Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8	Human	Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11	Human	Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12	Human	Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
KSP-Cadherin/CDH16	Human	Homo sapiens Cadherin-16/CDH16 cDNA Clone(NM_004062.2)
Cadherin-17/LI-cadherin	Human	Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone

E-Cadherin Background

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

E-Cadherin Related Studies

1. Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
2. Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
3. Mărgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.