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E-Cadherin Protein & Antibody (CDH1, CD324)

Epithelial-Cadherin (Cadherin 1/Cluster of Differentiation 324)

E-Cadherin Products

E-Cadherin Protein, Recombinant

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
E-Cadherin/CDH1/CD324 Human E-Cadherin / CDH1 / /CD324 Protein, Recombinant 10204-H08H
E-Cadherin/CDH1/CD324 Mouse E-Cadherin / CDH1 / CD324 Protein, Recombinant 50671-M08H
E-Cadherin/CDH1/CD324 Rat E-cadherin / CDH1 / Cadherin-1 Protein, Recombinant 80274-R02H

  10204-H08H:  When cells are added to E-Cad coated plates (1.5 µg/mL, 100 µL/well) , approximately 60 %-80 % will adhere specifically. Measured by the ability of the immobilized protein to support the adhesion of MCF-7 human breast adenocarcinoma cells.

E-Cadherin Antibody

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human
E-Cadherin/CDH1/CD324
WB, ELISA, ICC/IF, IF Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody 10204-MM04
Human
E-Cadherin/CDH1/CD324
WB, ELISA Cadherin-1 / CDH1 / CD324 / E-Cadherin Mouse MAb 10204-MM07
Human
E-Cadherin/CDH1/CD324
FCM Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody ( FITC ) 10204-MM08-F
Human
E-Cadherin/CDH1/CD324
FCM Cadherin-1 / CDH1 / CD324 / E-cadherin Antibody ( PE ) 10204-MM08-P
Human
E-Cadherin/CDH1/CD324
ELISA Cadherin-1 / CDH1 / CD324 / E-Cadherin Mouse MAb 10204-MM12
Human
E-Cadherin/CDH1/CD324
WB, ELISA E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb 10204-RP01
Human
E-Cadherin/CDH1/CD324
WB, ELISA E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb (Antigen Affinity Purified) 10204-RP02
Mouse
E-Cadherin/CDH1/CD324
WB, ELISA E-Cadherin / CDH1 / CD324 / Cadherin-1 Rabbit PAb (Antigen Affinity Purified) 50671-RP02

E-Cadherin ELISA Kit

Molecule Application Description //For Detailed Info. and Price------CLICK! Cat. No
Human E-Cadherin/CDH1/CD324 ELISA E-Cadherin / CDH1 / CD324 ELISA Kit SEK10204

E-Cadherin cDNA Clone

Molecule Species Description //For Detailed Info. and Price------CLICK! Cat. No
E-Cadherin/CDH1/CD324 Human E-Cadherin / CDH1 / CD324 cDNA Clone / ORF Clone HG10204-G
E-Cadherin/CDH1/CD324 Human Human E-Cadherin ORF Expression Clone, FLAG-tagged HG10204-G-F
E-Cadherin/CDH1/CD324 Rat E-Cadherin / CDH1 / CD324 cDNA Clone / ORF Clone RG80274-G

E-Cadherin Related Areas

Cardiovascular>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Stem Cell>>Hematopoietic Stem Cell (HSC)>>Hemangioblast>>Hemangioblast Marker>>E-Cadherin/CDH1/CD324

Stem Cell>>Embryonic Stem Cell (ESC)>>Embryonic Stem Cell Marker>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Stem Cell (CSC)>>E-Cadherin/CDH1/CD324

Cancer>>Angiogenesis>>Adhesion Molecules in Angiogenesis>>E-Cadherin/CDH1/CD324

Cancer>>Cancer Biomarkers>>E-Cadherin/CDH1/CD324

Immunology>>Adhesion Molecule>> Cadherin>>E-Cadherin/CDH1/CD324

Immunology>>Innate Immunity>>Natural Killer Cell (NK Cell)>>E-Cadherin/CDH1/CD324

Immunology>>Cluster of Differentiation>>Other>>E-Cadherin/CDH1/CD324

E-Cadherin Alternative Names

E-Cadherin, CDH1, CD324, Arc-1, CDHE, ECAD, LCAM, UVO [Homo sapiens]

E-Cadherin, Cdh1, Ecad, L-CAM, AA960649, MGC107495, UVO, Um [Mus musculus]

E-Cadherin Related Products

Protein Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
N-Cadherin/CD325/CDH2 Human N-Cadherin/CD325/CDH2 Protein, Recombinant
R-Cadherin/CDH4 Human R-Cadherin/CDH4 Protein, Recombinant
VE-Cadherin/CD144/CDH5 Human VE-Cadherin/CD114/Fc Protein, Recombinant
VE-Cadherin/CD144/CDH5 Mouse VE-Cadherin/CD144/CDH5 Protein, Recombinant
Cadherin-6/K-Cadherin/CDH6 Human Cadherin-6/K-Cadherin/CDH6 Protein, Recombinant
Cadherin-8/CDH8 Human Cadherin-8/CDH8 Protein, Recombinant
Cadherin-12/CDH12 Human Cadherin-12/CDH12 Protein, Recombinant
KSP-Cadherin/Cadherin-16/CDH16 Human KSP-Cadherin/Cadherin-16/CDH16 Protein, Recombinant
Cadherin-17/LI-cadherin Human Cadherin-17/LI-cadherin Protein, Recombinant

Antibody Products

Molecule Applications Description //For Detailed Info. and Price------CLICK!
Human
R-Cadherin/CDH4
WB, ELISA R-Cadherin/CDH4 Antibody, Rabbit PAb
Human
R-Cadherin/CDH4
WB, ELISA R-Cadherin/CDH4 Antibody, Rabbit PAb (Antigen Affinity Purified)
Mouse
VE-Cadherin/CD144/CDH5
WB, ELISA Rabbit Polyclonal Antibody

cDNA Clone Products

Molecule Species Description //For Detailed Info. and Price------CLICK!
N-Cadherin/CD325/CDH2 Human Homo sapiens N-Cadherin/CD325/CDH2 cDNA Clone(NM_001792.3)
P-Cadherin/CDH3 Human Homo sapiens P-Cadherin/CDH3 cDNA Clone(NM_001793.4)
VE-Cadherin/CD144/CDH5 Human Homo sapiens VE-Cadherin/CD144/CDH5 cDNA Clone(NM_001795.3)
VE-Cadherin/CD144/CDH5 Mouse Mus musculus VE-Cadherin/CD114/CDH5 cDNA Clone
Cadherin-6/K-Cadherin/CDH6 Human Homo sapiens Cadherin-6/K-Cadherin/CDH6 cDNA Clone(NM_004932.2)
Cadherin-8/CDH8 Human Homo sapiens Cadherin-8/CDH8 cDNA Clone(NM_001796.2)
Cadherin-11/CDH11 Human Homo sapiens Cadherin-11/CDH11 cDNA Clone(NM_001797.2)
Cadherin-12/CDH12 Human Homo sapiens Cadherin-12/CDH12 cDNA Clone(NM_004061.3)
KSP-Cadherin/CDH16 Human Homo sapiens Cadherin-16/CDH16 cDNA Clone(NM_004062.2)
Cadherin-17/LI-cadherin Human Homo sapiens Cadherin-17/LI-cadherin/CDH17 cDNA Clone

E-Cadherin Background

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

E-Cadherin Related Studies

  1. Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  2. Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  3. Mărgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.

 

 

E-Cadherin/CDH1/E-cad/CD324 related areas, pathways, and other information

 

 

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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