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E-Cadherin/CDH1/E-cad/CD324 Rabbit PAb , Antigen Affinity Purified

  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunoprecipitation
  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
  • E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
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Mouse CDH1 Antibody Product Information
Immunogen:Recombinant Mouse E-Cadherin / CDH1 protein (Catalog#50671-M08H)
Clone ID:
Ig Type:Rabbit IgG
Concentration:
Endotoxin:
Formulation:0.2 μm filtered solution in PBS
Preparation:Produced in rabbits immunized with purified, recombinant Mouse E-Cadherin / CDH1 (rM E-Cadherin / CDH1; Catalog#50671-M08H; P09803; Met 1-Val 709). E-Cadherin / CDH1 specific IgG was purified by Mouse E-Cadherin / CDH1 affinity chromatography.
Mouse CDH1 Antibody WB Application Image
Mouse CDH1 Antibody IHC Application Image
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CDH1 in mouse liver with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
E-Cadherin / CDH1 / E-cad / CD324 Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
[Click to enlarge image]
Caption:
Immunochemical staining of mouse CDH1 in mouse stomach with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). The left panel: tissue incubated with primary antibody; The right panel: tissue incubated with the mixture of primary antibody and antigen (recombinant protein).
Mouse CDH1 Antibody IP Application Image
Other CDH1 Antibody Products
E-Cadherin/CDH1/E-cad/CD324 Background

Cadherins are calcium-dependent cell adhesion proteins which preferentially interact with themselves in a homophilic manner in connecting cells, and thus may contribute to the sorting of heterogeneous cell type. E-cadherin (E-Cad), also known as CDH1 and CD324, is a calcium-dependent cell adhesion molecule the intact function of which is crucial for the establishment and maintenance of epithelial tissue polarity and structural integrity. Mutations in CDH1 occur in diffuse type gastric cancer, lobular breast cancer, and endometrial cancer. In human cancers, partial or complete loss of E-cadherin expression correlates with malignancy. During apoptosis or with calcium influx, E-Cad is cleaved by the metalloproteinase to produce fragments of about 38 kDa (E-CAD/CTF1), 33 kDa (E-CAD/CTF2) and 29 kDa (E-CAD/CTF3), respectively. E-Cad has been identified as a potent invasive suppressor, as downregulation of E-cadherin expression is involved in dysfunction of the cell-cell adhesion system, and often correlates with strong invasive potential and poor prognosis of human carcinomas.

Mouse E-Cadherin/CDH1/E-cad/CD324 References
  • Wang HD, et al. (2004) CDH1 germline mutation in hereditary gastric carcinoma. World J Gastroenterol. 10(21): 3088-93.
  • Masterson J, et al. (2007) Posttranslational truncation of E-cadherin and significance for tumour progression. Cells Tissues Organs. 185(1-3): 175-9.
  • Mrgineanu E, et al. (2008) Correlation between E-cadherin abnormal expressions in different types of cancer and the process of metastasis. Rev Med Chir Soc Med Nat Iasi. 112(2): 432-6.
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    Catalog: 50671-RP02-50
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    Datasheet & Documentation

    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"