DKK1 cDNA ORF Clone, Human, untagged

Cat: HG10170-M-N
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All DKK1 Reagents
DKK1 cDNA ORF Clone, Human, untagged General Information
NCBI Ref Seq
RefSeq ORF Size
801 bp
Sequence Description
Identical with the Gene Bank Ref. ID sequence.
ORF Clone of Human dickkopf homolog 1 (Xenopus laevis) DNA.
Restriction Sites
KpnI + XhoI
Quality Control
The plasmid is confirmed by full-length sequencing.
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
DKK1 cDNA ORF Neucleotide Sequence and Amino Acid Sequence Information

**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**

DKK1 cDNA ORF Clone, Human, untagged Validated Images
other Green fluorescent protein / GFP Gene Plasmid Map 7139
DKK1 cDNA ORF Clone, Human, untagged Alternative Names
DKK-1 cDNA ORF Clone, Human;SK cDNA ORF Clone, Human
DKK1 Background Information

Dickkopf (DKK) family proteins, consisting of DKK-1, DKK-2, DKK-3 and DKK-4, function as secreted Wnt antagonists by inhibiting Wnt coreceptors LRP5/6. DKK-1, DKK-2, and DKK-4 also bind cell surface Kremen-1 or Kremen-2 and promote the internalization of LRP5/6. Dickkopf related protein 1 (DKK-1) was initially identified as an inducer of head formation in Xenopus embryos. DKK-1 protein modulates Wnt signaling pathway during embryonic development. Increased levels of DKK-1 are found in the majority of lung cancers, esophageal squamous cell carcinomas, and hormone-resistant breast cancers, while DKK-1 expression is decreased in malignant melanoma and colorectal cancers.

Full Name
dickkopf WNT signaling pathway inhibitor 1
  • Horwitz EM. (2004) Dkk-1-mediated expansion of adult stem cells. Trends Biotechnol. 22(8): 386-8.
  • Jiang T, et al. (2009) Clinical significance of serum DKK-1 in patients with gynecological cancer. Int J Gynecol Cancer. 19(7): 1177-81.
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