Anti-TXNL4B Antibody

Cat: 13501-RP01
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Anti-TXNL4B Antibody (Rabbit Polyclonal antibody) General Information
Product name
Anti-TXNL4B Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TXNL4B
Immunogen
Recombinant Human Dim2 / TXNL4B protein (Catalog#13501-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human Dim2 / TXNL4B (rh Dim2 / TXNL4B; Catalog#13501-H07E; Q9NX01; Met1-Ile149). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TXNL4B Antibody (Rabbit Polyclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:1000-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-TXNL4B Antibody Alternative Names
Anti-Dim2 Antibody;Anti-DLP Antibody
TXNL4B Background Information

Dim2, also known as TXNL4B, is a member of the DIM1 family. The Dim protein family is composed of two classes, Dim1and Dim2, which share a common thioredoxin-like fold. They were originally identified for their role in cell cycle progression and have been found to interact with Prp6, an essential component of the spliceosome, which forms the bridge of U4/U6.U5-tri-snRNP. In spite of their biological and structural similarities, Dim1 and Dim2 proteins differ in many aspects. Dim1 bears distinctive structural motifs responsible for its interaction with other spliceosome components. Dim2 forms homodimers and contains specific domains required for its interactions with partners. This originality suggests that although both proteins are involved in pre-mRNA splicing, they are likely to be involved in different biological pathways. Dim2 roduced in E.Coli is a single, non-glycosylated polypeptide chain containing 185 amino acids and having a molecular mass of 21.1kDa. It is fused to a 36 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Dim2 has a vital role in pro-mRNA splicing. Dim2 is required in cell cycle progression for S/G2 transition and interacts with PRPF6 subunit of the spliceosome.

Full Name
thioredoxin-like 4B
References
  • Sun X, et al. (2004) DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression. J Biol Chem. 279(31):32839-47.
  • Maruyama K, et al. (1994) Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Gene. 138(1-2):171-4.
  • Suzuki Y, et al. (1997) Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. Gene. 200(1-2):149-56.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-TXNL4B Antibody Rabbit Monoclonal ELISA 13501-R002
    Anti-TXNL4B Antibody Rabbit Polyclonal ELISA 13501-T16
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