Dectin-1 / CLEC7A Protein & Antibody

C-type lectin domain family 7, member A

Dectin-1 / CLEC7A  Products

Dectin-1 / CLEC7A Protein, Recombinant

Molecule	Species	Description	Cat. No
Dectin-1/CLEC7A	Mouse	Dectin-1/CLEC7A Protein, Recombinant	50233-M07H

Dectin-1 / CLEC7A Antibody

Molecule	Application	Description	Cat. No
Mouse Dectin-1/CLEC7A	WB, ELISA	Dectin-1/CLEC7A Antibody, Rabbit PAb	50233-RP01
Mouse Dectin-1/CLEC7A	WB, ELISA	Dectin-1/CLEC7A Antibody, Rabbit PAb (Antigen Affinity Purified)	50233-RP02

Dectin-1 / CLEC7A cDNA Clone

Molecule	Species	Description	Cat. No
Dectin-1/CLEC7A	Human	Homo sapiens Dectin-1/CLEC7A transcript variant 1DNA ORF Clone(NM_197947.2)	HG10215-M
Dectin-1/CLEC7A	Mouse	Mus musculus Dectin-1/CLEC7A cDNA Clone	MG50233-M

Dectin-1 / CLEC7A Related Areas

Immunology>>Adaptive Immunity>>Costimulation & Costimulatory Molecule>>Dectin-1/CLEC7A

Immunology>>Adhesion Molecule>>Lectin>>Dectin-1/CLEC7A

Immunology>>Adaptive Immunity>>T Cell>>T Cell Antigen Recognition>>Dectin-1/CLEC7A

Dectin-1 / CLEC7A Alternative Names

Dectin-1, CLEC7A, beta-glucan receptor, BGR, CANDF4, CLECSF12, DECTIN1 [Homo sapiens]

Dectin-1, Clec7a, beta-glucan receptor, BGR, Clecsf12, beta-GR [Mus musculus]

Dectin-1 / CLEC7A Background

Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.

Dectin-1 / CLEC7A Related Studies

1. Herre J, et al. (2004) The role of Dectin-1 in antifungal immunity. Crit Rev Immunol. 24(3): 193-203.
2. Brown GD. (2006) Dectin-1: a signalling non-TLR pattern-recognition receptor. 6(1): 33-43.
3. Sun L, et al. (2007) The biological role of dectin-1 in immune response. Int Rev Immunol. 26(5-6): 349-64.
4. Schorey JS, et al. (2008) The pattern recognition receptor Dectin-1: from fungi to mycobacteria. Curr Drug Targets. 9(2): 123-9.
5. Reid DM, et al. (2009) Pattern recognition: recent insights from Dectin-1. Curr Opin Immunol. 21(1): 30-7.