All Dectin-1 reagents are produced in house and quality controlled, including 5 Dectin-1 Antibody, 36 Dectin-1 Gene, 4 Dectin-1 Lysate, 4 Dectin-1 Protein, 2 Dectin-1 qPCR. All Dectin-1 reagents are ready to use.
Recombinant Dectin-1 proteins are expressed by HEK293 Cells with fusion tags as N-cleavage, N-human IgG1-Fc, N-mouse IgG1-Fc, N-His.
Dectin-1antibodies are validated with different applications, which are FCM, ICC/IF, IF, ELISA.
Dectin-1cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each Dectin-1 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Dectin-1 was recently identified as the most important receptor for beta-glucan. It is a type II transmembrane protein which binds beta-1,3 and beta-1,6 glucans, and is expressed on most cells of the innate immune system and has been implicated in phagocytosis as well as killing of fungi by macrophages, neutrophils and dendritic cells. Recognition of beta-glucan by dectin-1 triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi, which especially benefits immunocompromised patients against opportunistic fungal infection. In addition, dectin-1 is involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. Dectin-1 can recognize and respond to live fungal pathogens and is being increasingly appreciated as having a key role in the innate responses to these pathogens. In addition to its exogenous ligands, Dectin-1 can recognize an unidentified endogenous ligand on T cells and may act as a co-stimulatory molecule. Recent studies have highlighted the importance of Dectin-1 in anti-fungal immunity, in both mice and humans, and have suggested a possible involvement of this receptor in the control of mycobacterial infections.