Decorin Protein & Antibody

Decorin Products

Decorin Protein, Recombinant

Molecule	Species	Description	Cat. No
Decorin	Human	Decorin/Fc Protein, Recombinant	10189-H01H
Decorin	Human	Decorin Protein, Recombinant	10189-H08H

Decorin Antibody

Molecule	Application	Description	Cat. No
Human Decorin	WB, ELISA	Decorin Antibody, Rabbit MAb	10189-R004
Human Decorin	WB, ELISA	Decorin Antibody, Rabbit PAb	10189-RP01
Human Decorin	WB, ELISA	Decorin Antibody, Rabbit PAb (Antigen Affinity Purified)	10189-RP02

Decorin cDNA Clone

Molecule	Species	Description	Cat. No
Decorin	Human	Homo sapiens Decorin transcript variant A1 cDNA Clone(NM_001920.3)	HG10189-M

Decorin Alternative Names

Decorin, DCN, SLRR1B, DSPG2, CSCD, PG40, PGII, PGS2 [Homo sapiens]

Decorin, Dcn, SLRR1B, DSPG2, DC, PG40, PGII, PGS2, mDcn [Mus musculus]

Decorin Related Areas

Stem Cell>>Mesenchymal Stem Cell (MSC)>>Osteoblast & Osteoclast Marker>>Decorin

Cancer>>Cancer Stem Cell (CSC)>>Decorin

Cancer>>Angiogenesis>>ECM Molecules in Angiogenesis>>Decorin

Cancer>>Growth Factor & Receptor>>TGF-beta Superfamily>>TGF-beta Family>>Decorin

Immunology>>Adhesion Molecule>>Extracellular Matrix Molecule>>Proteoglycan>>Decorin

Immunology>>Cytokine & Receptor>>TGF-beta Superfamily>> TGF-beta Superfamily Modulators>>Decorin

Decorin Related Products

Protein Products

Molecule	Species	Description
TGF-beta 1	Human	Latent TGF-beta 1 protein, Recombinant
ALK-1/ACVRL1	Human	ALK-1/ACVRL1/Fc Protein, Recombinant
ALK-1/ACVRL1	Human	ALK-1/ACVRL1 Protein, Recombinant
ALK-1/ACVRL1	Mouse	ALK-1/ACVRL1/Fc Protein, Recombinant
Endoglin/CD105	Human	Endoglin/CD105/Fc Protein, Recombinant
TGFBR2	Human	TGFBR2/Fc Protein, Recombinant

cDNA Clone Products

Molecule	Species	Description
TGF-beta 1	Human	Homo sapiens TGF-beta 1 cDNA Clone(NM_000660.3)
TGF-beta 2	Human	Homo sapiens TGF-beta2 transcript variant 2 cDNA Clone(NM_003238.2)
TGF-beta 3	Human	Homo sapiens TGF-beta 3 cDNA Clone(NM_003239.2)
ALK-1/ACVRL1	Human	Homo sapiens ALK-1/ACVRL1 transcript variant 1 cDNA Clone(NM_000020.2)
ALK-7	Human	Homo sapiens ALK-7 cDNA Clone(NM_145259.2)
Cripto/TDGF1	Human	Homo sapiens Cripto/TDGF1 cDNA Clone(NM_003212.2)
Endoglin/CD105	Human	Homo sapiens Endoglin/CD105 transcript variant 1 cDNA Clone(NM_001114753.1)
TGFBR1/ALK-5	Human	Homo sapiens TGFBR1/ALK-5 cDNA Clone(NM_004612.2)
TGFBR2	Human	Homo sapiens TGFBR2 transcript variant 2 cDNA Clone(NM_003242.5)
BAMBI/NMA	Human	Homo sapiens BAMBI/NMA cDNA Clone(NM_012342.2)
Smad1	Human	Homo sapiens Smad1 cDNA Clone(NM_001003688.1)
Smad2	Human	Homo sapiens Smad2 transcript variant 2 cDNA Clone(NM_001003652.2)
Smad3	Human	Homo sapiens Smad3 cDNA Clone(NM_005902.3)
Smad5	Human	Homo sapiens Smad5 transcript variant 3 cDNA Clone(NM_001001420.1)

Decorin Background

Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.

Decorin Related Studies

1. Mogyorósi A, et al. (1999) What is the role of decorin in diabetic kidney disease? Nephrol Dial Transplant. 14(5): 1078-81.
2. Reed CC, et al. (2002) The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J. 19(4-5): 249-55.
3. Goldoni S, et al. (2008) Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer. 123(11): 2473-9.