Anti-Decorin Antibody

Cat: 10189-R004
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Anti-Decorin Antibody (Rabbit Monoclonal antibody) General Information
Product name
Anti-Decorin Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human Decorin
Immunogen
Recombinant Human Decorin protein (Catalog#10189-H08H)
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Decorin (rh Decorin; Catalog#10189-H08H; NP_001911.1; Met 1-Lys 359).
Source
Monoclonal Rabbit IgG Clone #004
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Decorin Antibody (Rabbit Monoclonal antibody) Validated Applications
Application Dilution Notes
ELISA 1:5000-1:10000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-Decorin Antibody Alternative Names
Anti-CSCD Antibody;Anti-DSPG2 Antibody;Anti-PG40 Antibody;Anti-PGII Antibody;Anti-PGS2 Antibody;Anti-SLRR1B Antibody
Decorin Background Information

Decorin is a ubiquitous small cellular or pericellular matrix proteoglycan and is closely related in structure to biglycan protein. It belongs to the small leucine-rich proteoglycan (SLRP) family and consists of a core protein and a covalently linked glycosaminoglycan chain which is either chondroitin sulfate (CS) or dermatan sulfate (DS). As a component of connective tissue, decorin interacts with several extracellular matrix components, such as type I collagen and fibronectin, and plays a role in matrix assembly. Decorin resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth factor receptor and other members of the ErbB family of receptor tyrosine kinases. It exerts its antitumor activity by a dual mechanism: via inhibition of these key receptors through their physical downregulation coupled with attenuation of their signaling, and by binding to and sequestering TGFbeta. Decorin also modulates the insulin-like growth factor receptor and the low-density lipoprotein receptor-related protein 1, which indirectly affects the TGFbeta receptor pathway. Decorin plays significant roles in tissue development and assembly, as well as playing both direct and indirect signaling roles.

Full Name
decorin
References
  • Mogyorsi A, et al. (1999) What is the role of decorin in diabetic kidney disease? Nephrol Dial Transplant. 14(5): 1078-81.
  • Reed CC, et al. (2002) The role of decorin in collagen fibrillogenesis and skin homeostasis. Glycoconj J. 19(4-5): 249-55.
  • Goldoni S, et al. (2008) Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. Int J Cancer. 123(11): 2473-9.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-Decorin Antibody Rabbit Polyclonal ELISA 10189-RP01
    Anti-Decorin Antibody Rabbit Polyclonal ELISA 10189-RP02
    Anti-Decorin Antibody Rabbit Polyclonal ELISA 10189-T16
    info info
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