All DcR3 reagents are produced in house and quality controlled, including 1 DcR3 Antibody, 13 DcR3 Gene, 1 DcR3 Lysate, 1 DcR3 Protein, 1 DcR3 qPCR. All DcR3 reagents are ready to use.
Recombinant DcR3 proteins are expressed by Baculovirus-Insect Cells, HEK293 Cells with fusion tags as C-human IgG1-Fc, C-His.
DcR3antibodies are validated with different applications, which are IHC-P, ICC/IF, IF.
DcR3cDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each DcR3 of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This protein is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.