DcR3 / TNFRSF6B Protein

Decoy Receptor 3 / Tumor Necrosis Factor Receptor Superfamily, member 6b, decoy

DcR3 / TNFRSF6B Products

DcR3 / TNFRSF6B Protein, Recombinant

Molecule	Species	Description	Cat. No
DcR3/TNFRSF6B	Human	DcR3/TNFRSF6B Protein, Recombinant	10224-H08H

DcR3 / TNFRSF6B cDNA Clone

Molecule	Species	Description	Cat. No
DcR3/TNFRSF6B	Human	Homo sapiens DcR3/TNFRSF6B transcript variant M68E cDNA Clone	HG10224-M

DcR3 / TNFRSF6B Related Areas

Immunology>>Cytokine & Receptor>>TNF Superfamily>>DcR3/TNFRSF6B

DcR3 / TNFRSF6B Alternative Names

DCR3, TNFRSF6B, hCG_2044836, DJ583P15.1.1, M68, TR6 [Homo sapiens]

DcR3 / TNFRSF6B Background

Tumor necrosis factor receptor superfamily member 6B (TNFRSF6B) also known as DcR3(Decoy Receptor 3) and M68 is the tumor necrosis factor receptor superfamily. DcR3/TNFRSF6B belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. DcR3/TNFRSF6B is detected in fetal lung, brain and liver. DcR3/TNFRSF6B is also detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. This protein is highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

DcR3 / TNFRSF6B Related Studies

1. Migone TS, et al. (2002) TL1A is a TNF-like ligand for DR3 and TR6/DcR3 and functions as a T cell costimulator. Immunity. 16(3): 479-92.
2. Takahama Y, et al. (2002) The prognostic significance of overexpression of the decoy receptor for Fas ligand (DcR3) in patients with gastric carcinomas. Gastric Cancer. 5(2): 61-8.
3. Zhang J, et al. (2001) Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin Invest. 107(11): 1459-68.