DYDC2 Protein (GST Tag)

DPY30 domain containing 2 Protein Datasheet

DYDC2 Protein Product Information

• Synonym: DYDC2
• Protein Construction: A DNA sequence encoding the mature form of human DYDC2 (Q96IM9) (Thr102-Pro176) was fused with the GST tag at the N-terminus.
• Source: Human
• Expression Host: E.coli

DYDC2 Protein QC Testing

• Purity: > 93 % as determined by SDS-PAGE
• Endotoxin: Please contact us for more information.
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Predicted N terminal: Met
• Molecular Mass: The recombinant human DYDC2 /GST chimera consists of 307 amino acids and has a predicted molecular mass of 35.5 kDa. It migrates as an approximately 37 KDa band in SDS-PAGE under reducing conditions.
• Formulation: Lyophilized from sterile PBS, pH7.4.
  1. Normally 5 % - 8 % trehalose and mannitol are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
  2. Please contact us for any concerns or special requirements.
• SDS-PAGE: DYDC2 protein

DYDC2 Protein Usage Guide

• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

DYDC2 Protein Description

DPY30 domain containing 2 is a member of the dpy-30 family. Members of this family act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 binds to metal response elements (MREs) and plays a key role in transition metal detoxification and homeostasis. Dpy-30 is the founding member of a protein family involved in chromatin modifications, notably histone methylation. Mutants affect mating type in yeast and male mating in C. elegans. As part of the MLL1/MLL complex, DPY30 domain containing 2 is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. DPY30 domain containing 2 may also play an indirect or direct role in endosomal transport.

References

1. Deloukas P. et al., 2004, Nature. 429 (6990): 375-81.
2. Rual JF. et al., 2005, Nature. 437 (7062): 1173-8.
3. Xin X. et al., 2009, Genome Res. 19 (7): 1262-9.